Kramer ML, Schulz-Schaeffer WJ.
Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies.
J Neurosci. 2007 Feb 7;27(6):1405-10.
PubMed.
The authors have carried out a fundamental work on Septin, a scaffolding protein. It does play a dual role in the dopaminergic neurons by organizing the dopamine neurons for better neurotransmission and also protects the accumulation of pathological forms of synuclein.
It would be even more precise to study the effect of septin on the oligomers (considered to be the toxic species in the filament formation) in the cell lines by its expression.This study indirectly speaks about the neuronal vulnerability and selective cell death of the dopaminergic neurons to a certain extent.
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Johns Hopkins Univ School of Medicine
The authors have carried out a fundamental work on Septin, a scaffolding protein. It does play a dual role in the dopaminergic neurons by organizing the dopamine neurons for better neurotransmission and also protects the accumulation of pathological forms of synuclein.
It would be even more precise to study the effect of septin on the oligomers (considered to be the toxic species in the filament formation) in the cell lines by its expression.This study indirectly speaks about the neuronal vulnerability and selective cell death of the dopaminergic neurons to a certain extent.
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