International Multiple Sclerosis Genetics Consortium (IMSGC). Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci. Hum Mol Genet. 2010 Mar 1;19(5):953-62. Epub 2009 Dec 9 PubMed.

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Research Models

  1. Trem2 R47H KI x APOE4 (LOAD1)
  2. Kif21b*T82T/APOE4/Trem2*R47H