van Steenoven I, Majbour NK, Vaikath NN, Berendse HW, van der Flier WM, van de Berg WD, Teunissen CE, Lemstra AW, El-Agnaf OM. α-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies. Mov Disord. 2018 Nov;33(11):1724-1733. Epub 2018 Nov 15 PubMed.
AlzBiomarker Database
Meta-Analysis
- PD vs AD : Aβ42 (CSF)
- PD vs AD : tau-p181 (CSF)
- PD vs AD : tau-total (CSF)
- AD vs CTRL : α-synuclein (CSF)
- CTRL vs AD : α-synuclein (CSF)
- DLB vs AD : α-synuclein (CSF)
- PD vs AD : α-synuclein (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ42 (CSF) |
AD (35) |
486 ± 194 pg/mL |
ELISA; Innotest; Fujirebio |
McKhann et al., 2011 |
| Aβ42 (CSF) |
PD- non-demented (46) |
917 ± 211 pg/mL |
ELISA; Innotest; Fujirebio |
Hughes et al., 1992 |
| tau-p181 (CSF) |
AD (35) |
84 ± 36 pg/mL § |
ELISA; Innotest; Fujirebio |
McKhann et al., 2011 |
| tau-p181 (CSF) |
PD- non-demented (46) |
41 ± 16 pg/mL § |
ELISA; Innotest; Fujirebio |
Hughes et al., 1992 |
| tau-total (CSF) |
AD (35) |
630 ± 289 pg/mL § |
ELISA; Innotest; Fujirebio |
McKhann et al., 2011 |
| tau-total (CSF) |
PD- non-demented (46) |
212 ± 91 pg/mL § |
ELISA; Innotest; Fujirebio |
Hughes et al., 1992 |
| α-synuclein (CSF) |
AD (34) |
2 ± 0.5 ng/mL |
ELISA; Other/Not Specified; In-house |
McKhann et al., 2011 |
| α-synuclein (CSF) |
CTRL- SCI (30) |
1.8 ± 0.6 ng/mL § |
ELISA; Other/Not Specified; In-house |
|
| α-synuclein (CSF) |
DLB (41) |
1.4 ± 0.4 ng/mL |
ELISA; Other/Not Specified; In-house |
McKeith et al., 2005 |
| α-synuclein (CSF) |
PD- non-demented (46) |
1.4 ± 0.3 ng/mL |
ELISA; Other/Not Specified; In-house |
Hughes et al., 1992 |
§ Data supplied to Alzforum by author
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