Janelidze S, Mattsson N, Stomrud E, Lindberg O, Palmqvist S, Zetterberg H, Blennow K, Hansson O. CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease. Neurology. 2018 Aug 28;91(9):e867-e877. Epub 2018 Jul 27 PubMed.
AlzBiomarker Database
Meta-Analysis
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| MCP-1 (CSF) |
AD (57) |
373.8 ± 117 pg/mL § |
Electrochemiluminescence; V-PLEX Neuroinflammation Panel 1 Human Kit; Meso Scale Discovery |
McKhann et al., 2011 |
| MCP-1 (CSF) |
CTRL- CNC, SCI, Aβ- (362) |
363.4 ± 99.2 pg/mL § |
Electrochemiluminescence; V-PLEX Neuroinflammation Panel 1 Human Kit; Meso Scale Discovery |
|
| YKL-40 (CSF) |
AD (57) |
241.5 ± 74.1 ng/mL § |
ELISA; Other/Not Specified; R&D Systems, Inc. |
McKhann et al., 2011 |
| YKL-40 (CSF) |
CTRL- CNC, SCI, Aβ- (362) |
180.4 ± 65.9 ng/mL § |
ELISA; Other/Not Specified; R&D Systems, Inc. |
§ Data supplied to Alzforum by author
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