Domínguez-del-Toro E, Rodríguez-Moreno A, Porras-García E, Sánchez-Campusano R, Blanchard V, Laville M, Böhme GA, Benavides J, Delgado-García JM. An in vitro and in vivo study of early deficits in associative learning in transgenic mice that over-express a mutant form of human APP associated with Alzheimer's disease. Eur J Neurosci. 2004 Oct;20(7):1945-52. PubMed.

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  1. This study is in good agreement with earlier work by Moechars et al., 1999, which demonstrates alterations in both cognitive function and synaptic plasticity in mice transgenic for human APP695 (V642I) several months before amyloid deposition is detectable.

    References:

    Moechars D, Dewachter I, Lorent K, Reversé D, Baekelandt V, Naidu A, Tesseur I, Spittaels K, Haute CV, Checler F, Godaux E, Cordell B, Van Leuven F. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem. 1999 Mar 5;274(10):6483-92. PubMed.

    View all comments by Dominic Walsh

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