Bae TJ, Kim MS, Kim JW, Kim BW, Choo HJ, Lee JW, Kim KB, Lee CS, Kim JH, Chang SY, Kang CY, Lee SW, Ko YG.
Lipid raft proteome reveals ATP synthase complex in the cell surface.
Proteomics. 2004 Nov;4(11):3536-48.
PubMed.
Alpha chain of ATP synthase is indeed a protein with many facets. One of them is that it binds to "early" tangles and could be therefore an interesting marker of the degenerating process in Alzheimer's disease.
References:
Sergeant N, Wattez A, Galván-valencia M, Ghestem A, David JP, Lemoine J, Sautiére PE, Dachary J, Mazat JP, Michalski JC, Velours J, Mena-López R, Delacourte A.
Association of ATP synthase alpha-chain with neurofibrillary degeneration in Alzheimer's disease.
Neuroscience. 2003;117(2):293-303.
PubMed.
Comments
Inserm
Alpha chain of ATP synthase is indeed a protein with many facets. One of them is that it binds to "early" tangles and could be therefore an interesting marker of the degenerating process in Alzheimer's disease.
References:
Sergeant N, Wattez A, Galván-valencia M, Ghestem A, David JP, Lemoine J, Sautiére PE, Dachary J, Mazat JP, Michalski JC, Velours J, Mena-López R, Delacourte A. Association of ATP synthase alpha-chain with neurofibrillary degeneration in Alzheimer's disease. Neuroscience. 2003;117(2):293-303. PubMed.
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