Hattori S, Sakuma K, Wakutani Y, Wada K, Shimoda M, Urakami K, Kowa H, Nakashima K. A novel presenilin 1 mutation (Y154N) in a patient with early onset Alzheimer's disease with spastic paraparesis. Neurosci Lett. 2004 Sep 30;368(3):319-22. PubMed.

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  1. This paper shows, one more time, that the very first clinical symptoms of FAD with early onset are not necessarily linked to memory.

    View all comments by Andre Delacourte

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Mutations

  1. PSEN1 Y154N