Miami: HAI Amyloid Imaging Conference Abstracts

Series - Human Amyloid Imaging 2011:

Below we list 66 of the 67 abstracts presented at the Human Amyloid Imaging Conference held 14-15 January 2011 in Miami, Florida. (One was withheld due to publication embargo.) All meeting abstracts are published in the Alzforum Papers of the Week database. The accompanying news series covers many but not all of these studies; hence, this document offers the curious reader a wealth of new data to peruse. The Alzforum editors thank co-organizer Keith Johnson for obtaining permission to publish the abstracts; we also acknowledge all the authors for their generosity in sharing their latest data with the worldwide Alzheimer 's disease research community.—Gabrielle Strobel.

Cohen AD, Price JC, Mathis CA, Nebes RD, Saxton JA, Snitz BE, Aizenstein HJ, Weissfeld LA, DeKosky ST, Klunk WE. Longitudinal changes in fibrillar amyloid-beta deposition across the cognitive spectrum. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15; Abstract

Rentz DM, Betensky RA, Becker JA, England RL, Maye J, Gidicsin C, Sperling RA, Johnson KA. Amyloid deposition in non-demented elderly predicts longitudinal cognitive decline. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Koivunen J, Scheinin N, Virta JR, Aalto S, Vahlberg T, Nagren K, Helin S, Parkkola R, Viitanen M, Rinne JO. PET imaging of beta-amyloid deposition in patients with mild cognitive impairment: a two year follow-up study. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Forster S, Grimmer T, Miederer I, Henriksen G, Yousefi BH, Greve D, Graner P, Wester H-J, Forstl H, Drzezga A. Regional expansion of cerebral hypometabolism in AD follows the pattern of amyloid-deposition with temporal delay and is related to a healthy functional connectivity network. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Mormino EC, Brandel MG, Madison CM, Jagust WJ. Increased prefrontal activation in amyloid positive cognitively normal individuals during successful episodic memory encoding. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Kennedy KM, Rodrigue KM, Hebrank AC, Devous Sr. MD, Park DC. Precuneus beta-amyloid burden is associated with decreased bilateral frontal activation and default network suppression in healthy adults. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Devous Sr. MD, Kennedy KM, Rodrigue KM, Hebrank AC, Park DC. Precuneus beta-amyloid burden correlates with altered cortical network function in a lifespan sample of healthy adults. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Vannini P, Hedden T, Sullivan C, Ward A, Becker JA, Johnson KA, Sperling RA. Age and amyloid deposition are associated with functional alterations in posteromedial cortex during encoding and retrieval processes. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Vemuri P, Jones DT, Machulda M, Przybelski SA, Boeve BF, Knopman DS, Petersen RC, Jack Jr. CR. Functional reorganization of the brain along the Alzheimer's disease continuum. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Nordberg A, Scholl M, Carter S, Kadir A, Almkvist O, Ng Y-B, Wall A, Engler H, Graff C, Langstrom B. Biomarkers for following Alzheimer's disease progression. Amyloid 11C-PIB imaging in a multi-tracer paradigm with 11C-d-deprenyl and 18F-FDG studied in preclinial and clinical AD. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Ishii K, Sakata M, Oda K, Toyohara J, Ishiwata K, Senda M, Ito K, Kuwano R, Iwatsubo T. Influence of APOE genotype on amyloid deposition in Japanese population. Direct comparison of J-ADNI, USADNI and AIBL 11C-PiB PET data. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Scheinin NM, Aalto S, Kaprio J, Koskenvuo M, Raiha I, Rokka J, Hinkka-Yli-Salomaki S, Rinne JO. Early detection of Alzheimer's. 11C-PIB PET in monozygotic and dizygotic twins discordant for cognitive impairment. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Rabinovici GD, Rosen HJ, Alkalay A, Trojanowski JQ, Grinberg LT, Huang EJ, Seeley WW, Miller BL, Jagust WJ. PIB versus FDG PET in pathologically verified dementia. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Wolk DA, Grachev ID, Buckley C, Arnold SE. 18F-flutemetamol amyloid imaging has strong concordance with cortical biopsy histopathology. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Driscoll I, Troncoso JC, Sojkova J, Zhou Y, Rudow G, Kraut MA, Ferrucci L, Mathis CA, Klunk WE, Resnick SM. Correspondence between in vivo PiB-PET amyloid imaging and post-mortem, regional burden of As and Tau lesions. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Johnson KA, Gidicsin C, Larvie M, Maye J, Carmasin J, Becker JA, Rentz D, Sperling RA. Microbleeds and amyloid-s burden in non-demented elderly. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Matthews DC, Andrews RD, Ordonez CE, Schmidt ME. Methodologic considerations in the acquisition and analysis of amyloid imaging data for pharmaceutical clinical trials. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Nelissen N, Van Laere K, Thurfjell L, Buckley C, Farrar G, Brooks DJ, Vandenberghe R. Support vector machine analysis of flutemetamol scans. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Bi W, Weissfeld LA, Cohen AD, Klunk WE, Mathis CA, Price JC. Exploration of the PiB positivity boundary using statistical clustering. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Landau SM, Price JC, Jagust WJ, Mathis CA. Reliability of longitudinal PIB: How do data processing methods influence detection of change over time? Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Tolboom N, Ossenkoppele R, Yaqub M, Boellaard R, Scheltens P, Lammertsma AA, van Berckel BNM. Longitudinal amyloid imaging using [11C]PIB: Choosing the right method. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Koeppe RA. Amyloid PET imaging in large multi-center trials: Technical and practical issues. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Xu G, Christian BT, Wooten DW, Hillmer AT, Murali D, Barnhart T, Harding S, Cleary C, Kastman EK, Johnson SC. The influence of amyloid burden on cerebral glucose metabolism and cognition in cognitively normal middle age subjects who have high risk for Alzheimer's disease. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Vlassenko AG, Couture L, Goate AM, Raichle ME, Morris JC, Mintun MA. Regional brain metabolism in cognitively normal elder individuals with various levels of cerebral beta-amyloid deposition. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Lee DY, Han Choo IL, Kim JW, Seo EH, Lee DS, Kim YK, Kim SG, Park SY, Woo JI. Relationship of amyloid-beta burden with age-at-onset in Alzheimer's disease. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Fleisher AS, Chen K, Roontiva A, Thiyyagura P, Liu X, Clark CM, Mintun MA, Pontecorvo MJ, Doraiswamy PM, Reiman EM. Multi-level fibrillar amyloid thresholds of florbetapir F18 PET images from five multi-center studies. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Langbaum JB, Chen K, Fleisher AS, Keppler J, Prouty A, Bandy D, Perkins M, Richter NK, Jakimovich L, Reiman EM. [18F]AZD4694 in the symptomatic and presymptomatic study of Alzheimer's disease Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

van Dyck CH, Bruck A, Barcelos NM, Planeta-Wilson B, Benincasa AL, MacAvoy MG, Ding YS, Gelernter J, Carson RE. Amyloid-s burden and neuropsychological test performance in cognitively normal first-degree relatives at varying genetic risk for Alzheimer's disease. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Marshall GA, Olson LE, Frey MT, Maye J, Rentz DM, Sperling RA, Johnson KA. Instrumental activities of daily living impairment is associated with increased amyloid burden. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Becker JT, Price J, Kingsley L, Minhas D, Teverovsky L, Rinaldo CR. PiB retention and neuropsychological test performance among cognitively normal men. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Shaffer JL, Petrella JR, Doraiswamy PM, Sheldon FC, MacCarthy MD, Calhoun VD. Predicting cognitive decline in MCI subjects using Fusion ICA Toolbox to combine multimodality biomarker data. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Rodrigue KM, Kennedy KM, Devous Sr. MD, Park DC. Beta-amyloid in healthy aging: regional distribution and cognitive consequences. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

England RL, Becker JA, Olson L, Frishe K, Frey MT, Maye J, Johnson KA, Sperling RA, Rentz DM. Predicting amyloid deposition using multiple neuropsychological measures. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Landau SM, Marks SM, Mormino EC, Rabinovici GD, Oh H, O'Neil JP, Wilson RS, Jagust WJ. Cognitive activity is associated with amyloid deposition in normal older individuals. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Sheldon FC, Petrella JR, Doraiswamy P. Voxel degree as a measure of functional connectivity changes in Alzheimer's disease. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Sepulcre J, Becker A, Hedden T, Sperling R, Buckner L, Johnson K. Hubs of atrophy and amyloid-s in AD and normal aging. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Wang L, Schultz A, Dickerson BC, Becker JA, Johnson KA, Sperling RA. Amyloid deposition disrupts local coupling of intrinsic brain activity in cognitively normal elderly. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Vemuri P, Wiste HJ, Knopman DS, Lowe V, Weiner M, Petersen RC, Jack Jr. CR. Effect of APOE on rate of change of PIB retention across the cognitive continuum. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Price JC, Weissfeld LA, Bi W, Cohen AD, Saxton JA, Snitz BE, Berginc M, DeKosky ST, Mathis CA, Klunk WE. Evaluation of longitudinal PiB data using linear mixed models. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Ossenkoppele R, Tolboom N, Foster-Dingley JC, Boellaard R, Yaqub M, Windhorst AD, van der Flier WM, Barkhof B, Lammertsma AA, van Berckel BNM. Time course of specific [11C]PIB and [18F]FDDNP binding: paired studies in patients with Alzheimer's disease, mild cognitive impairment and healthy controls. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Rinne JO, Suotunen T, Rummukainen J, Alafuzoff I, Savolainen S, Helin S, Seppala T, Herukka S-K, Koivisto A, Leinonen V. Brain [11C]-PiB uptake reflects beta-amyloid burden detected by immunohistochemistry in frontal cortex biopsy specimens. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Sur C, Hostetler E, Connolly BM, Miller PJ, O'Malley S, Chen T-B, Culberson C, Harrison S, Mulhearn J, Zeng Z. Pharmacological characterization of a novel fluorinated PET tracer for the detection of amyloid-s plaques. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Pontecorvo MJ, Joshi AD, Skovronsky DM, Mintun MA. Florbetapir F 18 and 11C-PIB PET imaging provide concordant measures of underlying brain amyloid pathology. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Ikonomovic MD, Abrahamson EE, Mathis CA, Debnath ML, Srinivasan S, Hamilton RL, Klunk WE. Comparison of [H-3]Flutemetamol and [H-3]PiB binding to cortical amyloid in brains from Alzheimer's disease and control subjects. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Duara R, Loewenstein DA, Shen Q, Barker W, Potter E, Varon D, Heurling K, Vandenberghe R, Buckley C. [18F]flutemetamol PET imaging and medial temporal atrophy measures in distinguishing aMCI and AD from elderly normals. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Cselenyi Z, Forsberg A, Jonhagen ME, Halldin C, Julin P, Schou M, Johnstrom P, Varnas K, Svensson S, Farde L. Head-to-head comparison of amyloid-specific PET radioligands [18F]AZD4694 and [11C]AZD2184. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Das BC, Das S, Elmaleh DR. Design and synthesis of potential retinoid based PET imaging agents to study Alzheimer's disease biology. Human Amyloid Imaging 2011 Meeting Abstrac. 2011 Jan 15. Abstract

Nabi HA, Sajjad M, Dhindsa S, Erb D, Wack D, Chaudhuri A, Dubey S, Wisniewski S, Dandona P. Quantitative measurement of B amyloid plaques with C-11 PIB positron emission tomography of hypogonadal men with type 2 diabetes. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

MacCarthy MD, Petrella JR, Sheldon FC, Shaffer JL, Doraiswamy PM, Calhoun VC. Multi-modality fusion of neuroimaging and genetic data in predicting abnormal cognitive decline in aging. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Kantarci K, Przybelski SA, Lowe V, Weigand SD, Senjem ML, Ivnik RJ, Roberts RO, Geda YE, Boeve BF, Jack Jr. CR. s-Amyloid deposition, 1H MRS metabolites and cognitive function in a population-based cohort of cognitively normal elderly. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Nyborg A, Moll J, Wegrzyn R, Havas D, Hutter-Paier B, Feuerstein G, Rudolph A. In vivo preclinical administration of a novel peptide based imaging agent for Alzheimer's disease. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Christian BT, Wooten DW, Hillmer AT, Tudorascu D, Murali D, Barnhart TE, Harding S, Asthana S, Sager MA, Johnson SC. The relation of serotonin 5-HT1A receptors and amyloid load in prodromal AD. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Carter SF, Scholl M, Almkvist O, Wall A, Engler H, Langstrom B, Nordberg A. Investigating astrocytosis with 11C-deuterium Deprenyl in mild cognitive impairment and mild Alzheimer's .A multi-tracer PET paradigm. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Sojkova J, Goh J, Beason-Held LL, Zhou Y, An Y, Kraut MA, Wong DF, Resnick SM. Increased s-amyloid deposition is related to regional cerebral blood flow in nondemented older adults. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Hedden T, Van Dijk K, Shire E, Sperling R, Johnson K, Buckner RL. Relationship of neuropathological markers of white matter burden and amyloid accumulation to attentional control during aging. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Cohen AD, Price JC, Rudolph M, Jones Z, Rosario BL, Weissfeld LA, Nebes RD, Saxton JA, Snitz BE, Klunk WE. Comparison of cerebral metabolism using the PALZ tool in clinically unimpaired elderly and MCI subjects with and without amyloid deposition. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Becker JA, Maye J, Gidicsin C, Rentz DR, Hedden T, Marshall G, Olson L, Buckner RL, Sperling RA, Johnson KA. FDG metabolism, amyloid deposition and APOE status in cognitively normal elderly subjects. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Rostomian A, Madison C, Rabinovici G, Jagust W. Early 11C-PIB frames and 18F-FDG measures are comparable. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Lopresti BJ, Klunk WE, Cohen A, Coleman R, Weissfeld L, Mathis CA, Price JC. Consideration of pons normalizing region for [11C]PIB PET scans. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Wack DS, Wisniewski S, Erb D, Dandona P, Nabi HA. Complex singular value decomposition improves the image quality of C11-PIB PET images. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Zubal G, Wisniewski G, Marek K, Seibyl J. Automated image quantification methods of PET betaamyloid scans. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Ng Y-B, Carter S, Scholl M, Kadir A, Nordberg A. Amyloid deposits in the cerebral cortex of patients with Alzheimer's disease align with cytoarchitectonic properties. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Thurfjell L, Lundqvist R, Lilja J, Vandenberghe R. A software application for automated analysis of [18F] flutemetamol amyloid imaging data. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Lowe VJ, Weigand SD, Jack Jr. CR, Kantarci K, Senjem ML, Petersen RC. Optimized ROI measures of FDG PET improve characterization of early cognitive impairment and are comparable to PIB PET. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Mathis CA, Holt DP, Huang GF, Lopresti BL, Debnath ML, Shao L, Klunk WE. Species-dependent metabolism of [C-11]PiB. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

Schmidt ME, Mortishire-Smith R, van Vlaslaer A, Christiaens T, Langlois X, Mackie C. Profiling of hepatic clearance pathways of PIB with cytochrome P450 phenotyping. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15. Abstract

This concludes a seven-part series of the HAI Amyloid Imaging conference. See also Part 1, Part 2, Part 3, Part 4, Part 5, and Part 6. View a PDF of the entire series.

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References

News Citations

  1. Miami: Women Rock at Human Amyloid Imaging Meeting
  2. Miami: Amyloid in the Aging Brain—What Does It Mean?
  3. Miami: Multimodal Imaging, New Way to Test Amyloid Hypothesis
  4. Miami: Astrocytes, Antidepressants, Microbleeds, and More
  5. Miami: Updates on J-ADNI, 18F Tracers, Biopsies
  6. Miami: Is Human Amyloid Imaging Ready for Clinical Trials?

Paper Citations

  1. Cohen AD, Price JC, Mathis CA, Nebes RD, Saxton JA, Snitz BE, Aizenstein HJ, Weissfeld LA, DeKosky ST, Klunk WE. Longitudinal changes in fibrillar amyloid-beta deposition across the cognitive spectrum. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  2. Rentz DM, Betensky RA, Becker JA, England RL, Maye J, Gidicsin C, Sperling RA, Johnson KA. Amyloid deposition in non-demented elderly predicts longitudinal cognitive decline. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  3. Koivunen J, Scheinin N, Virta JR, Aalto S, Vahlberg T, Nagren K, Helin S, Parkkola R, Viitanen M, Rinne JO. PET imaging of beta-amyloid deposition in patients with mild cognitive impairment: a two year follow-up study. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  4. Forster S, Grimmer T, Miederer I, Henriksen G, Yousefi BH, Greve D, Graner P, Wester H-J, Forstl H, Drzezga A. Regional expansion of cerebral hypometabolism in AD follows the pattern of amyloid-deposition with temporal delay and is related to a healthy functional connectivity network. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  5. Mormino EC, Brandel MG, Madison CM, Jagust WJ. Increased prefrontal activation in amyloid positive cognitively normal individuals during successful episodic memory encoding. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  6. Kennedy KM, Rodrigue KM, Hebrank AC, Devous Sr MD, Park DC. Precuneus beta-amyloid burden is associated with decreased bilateral frontal activation and default network suppression in healthy adults. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  7. Devous Sr MD, Kennedy KM, Rodrigue KM, Hebrank AC, Park DC. Precuneus beta-amyloid burden correlates with altered cortical network function in a lifespan sample of healthy adults. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  8. Vannini P, Hedden T, Sullivan C, Ward A, Becker JA, Johnson KA, Sperling RA. Age and amyloid deposition are associated with functional alterations in posteromedial cortex during encoding and retrieval processes. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  9. Vemuri P, Jones DT, Machulda M, Przybelski SA, Boeve BF, Knopman DS, Petersen RC, Jack Jr CR. Functional reorganization of the brain along the Alzheimer's disease continuum. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  10. Nordberg A, Scholl M, Carter S, Kadir A, Almkvist O, Ng Y-B, Wall A, Engler H, Graff C, Langstrom B. Biomarkers for following Alzheimer's disease progression. Amyloid 11C-PIB imaging in a multi-tracer paradigm with 11C-d-deprenyl and 18F-FDG studied in preclinial and clinical AD. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  11. Ishii K, Sakata M, Oda K, Toyohara J, Ishiwata K, Senda M, Ito K, Kuwano R, Iwatsubo T. Influence of APOE genotype on amyloid deposition in Japanese population. Direct comparison of J-ADNI, USADNI and AIBL 11C-PiB PET data. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  12. Scheinin NM, Aalto S, Kaprio J, Koskenvuo M, Raiha I, Rokka J, Hinkka-Yli-Salomaki S, Rinne JO. Early detection of Alzheimer's. 11C-PIB PET in monozygotic and dizygotic twins discordant for cognitive impairment. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  13. Rabinovici GD, Rosen HJ, Alkalay A, Trojanowski JQ, Grinberg LT, Huang EJ, Seeley WW, Miller BL, Jagust WJ. PIB versus FDG PET in pathologically verified dementia. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  14. Wolk DA, Grachev ID, Buckley C, Arnold SE. 18F-flutemetamol amyloid imaging has strong concordance with cortical biopsy histopathology. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  15. Driscoll I, Troncoso JC, Sojkova J, Zhou Y, Rudow G, Kraut MA, Ferrucci L, Mathis CA, Klunk WE, Resnick SM. Correspondence between in vivo PiB-PET amyloid imaging and post-mortem, regional burden of As and Tau lesions. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  16. Johnson KA, Gidicsin C, Larvie M, Maye J, Carmasin J, Becker JA, Rentz D, Sperling RA. Microbleeds and amyloid-s burden in non-demented elderly. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  17. Matthews DC, Andrews RD, Ordonez CE, Schmidt ME. Methodologic considerations in the acquisition and analysis of amyloid imaging data for pharmaceutical clinical trials. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  18. Nelissen N, Van Laere K, Thurfjell L, Buckley C, Farrar G, Brooks DJ, Vandenberghe R. Support vector machine analysis of flutemetamol scans. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  19. Bi W, Weissfeld LA, Cohen AD, Klunk WE, Mathis CA, Price JC. Exploration of the PiB positivity boundary using statistical clustering. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  20. Landau SM, Price JC, Jagust WJ, Mathis CA. Reliability of longitudinal PIB: How do data processing methods influence detection of change over time?. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  21. Tolboom N, Ossenkoppele R, Yaqub M, Boellaard R, Scheltens P, Lammertsma AA, van Berckel BN. Longitudinal amyloid imaging using [11C]PIB: Choosing the right method. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  22. Koeppe RA. Amyloid PET imaging in large multi-center trials: Technical and practical issues. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  23. Xu G, Christian BT, Wooten DW, Hillmer AT, Murali D, Barnhart T, Harding S, Cleary C, Kastman EK, Johnson SC. The influence of amyloid burden on cerebral glucose metabolism and cognition in cognitively normal middle age subjects who have high risk for Alzheimer's disease. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  24. Vlassenko AG, Couture L, Goate AM, Raichle ME, Morris JC, Mintun MA. Regional brain metabolism in cognitively normal elder individuals with various levels of cerebral beta-amyloid deposition. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  25. Lee DY, Han Choo IL, Kim JW, Seo EH, Lee DS, Kim YK, Kim SG, Park SY, Woo JI. Relationship of amyloid-beta burden with age-at-onset in Alzheimer's disease. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  26. Fleisher AS, Chen K, Roontiva A, Thiyyagura P, Liu X, Clark CM, Mintun MA, Pontecorvo MJ, Doraiswamy PM, Reiman EM. Multi-level fibrillar amyloid thresholds of florbetapir F18 PET images from five multi-center studies. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  27. Langbaum JB, Chen K, Fleisher AS, Keppler J, Prouty A, Bandy D, Perkins M, Richter NK, Jakimovich L, Reiman EM. [18F]AZD4694 in the symptomatic and presymptomatic study of Alzheimer's disease. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  28. van Dyck CH, Bruck A, Barcelos NM, Planeta-Wilson B, Benincasa AL, MacAvoy MG, Ding YS, Gelernter J, Carson RE. Amyloid-s burden and neuropsychological test performance in cognitively normal first-degree relatives at varying genetic risk for Alzheimer's disease. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  29. Marshall GA, Olson LE, Frey MT, Maye J, Rentz DM, Sperling RA, Johnson KA. Instrumental activities of daily living impairment is associated with increased amyloid burden. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  30. Becker JT, Price J, Kingsley L, Minhas D, Teverovsky L, Rinaldo CR. PiB retention and neuropsychological test performance among cognitively normal men. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  31. Shaffer JL, Petrella JR, Doraiswamy PM, Sheldon FC, MacCarthy MD, Calhoun VD. Predicting cognitive decline in MCI subjects using Fusion ICA Toolbox to combine multimodality biomarker data. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  32. Rodrigue KM, Kennedy KM, Devous Sr MD, Park DC. Beta-amyloid in healthy aging: regional distribution and cognitive consequences. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  33. England RL, Becker JA, Olson L, Frishe K, Frey MT, Maye J, Johnson KA, Sperling RA, Rentz DM. Predicting amyloid deposition using multiple neuropsychological measures. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  34. Landau SM, Marks SM, Mormino EC, Rabinovici GD, Oh H, O'Neil JP, Wilson RS, Jagust WJ. Cognitive activity is associated with amyloid deposition in normal older individuals. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  35. Sheldon FC, Petrella JR, Doraiswamy P. Voxel degree as a measure of functional connectivity changes in Alzheimer's disease. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  36. Sepulcre J, Becker A, Hedden T, Sperling R, Buckner L, Johnson K. Hubs of atrophy and amyloid-s in AD and normal aging. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  37. Wang L, Schultz A, Dickerson BC, Becker JA, Johnson KA, Sperling RA. Amyloid deposition disrupts local coupling of intrinsic brain activity in cognitively normal elderly. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  38. Vemuri P, Wiste HJ, Knopman DS, Lowe V, Weiner M, Petersen RC, Jack Jr CR. Effect of APOE on rate of change of PIB retention across the cognitive continuum. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  39. Price JC, Weissfeld LA, Bi W, Cohen AD, Saxton JA, Snitz BE, Berginc M, DeKosky ST, Mathis CA, Klunk WE. Evaluation of longitudinal PiB data using linear mixed models. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  40. Ossenkoppele R, Tolboom N, Foster-Dingley JC, Boellaard R, Yaqub M, Windhorst AD, van der Flier WM, Barkhof B, Lammertsma AA, van Berckel BN. Time course of specific [11C]PIB and [18F]FDDNP binding: paired studies in patients with Alzheimer's disease, mild cognitive impairment and healthy controls. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  41. Rinne JO, Suotunen T, Rummukainen J, Alafuzoff I, Savolainen S, Helin S, Seppala T, Herukka S-K, Koivisto A, Leinonen V. Brain [11C]-PiB uptake reflects beta-amyloid burden detected by immunohistochemistry in frontal cortex biopsy specimens. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  42. Sur C, Hostetler E, Connolly BM, Miller PJ, O'Malley S, Chen T-B, Culberson C, Harrison S, Mulhearn J, Zeng Z. Pharmacological characterization of a novel fluorinated PET tracer for the detection of amyloid-s plaques. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  43. Pontecorvo MJ, Joshi AD, Skovronsky DM, Mintun MA. Florbetapir F 18 and 11C-PIB PET imaging provide concordant measures of underlying brain amyloid pathology. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
  44. Ikonomovic MD, Abrahamson EE, Mathis CA, Debnath ML, Srinivasan S, Hamilton RL, Klunk WE. Comparison of [H-3]Flutemetamol and [H-3]PiB binding to cortical amyloid in brains from Alzheimer's disease and control subjects. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
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