CONFERENCE COVERAGE SERIES
Enabling Technologies for Alzheimer Disease Research: 2005 Bar Harbor Workshop
Bar Harbor, ME
07 – 10 September 2005
APP Function: A Report from Bar Harbor
In August 2005, a group of researchers from inside and outside the field of Alzheimer disease met in Bar Harbor, Maine, with foundation and NIH representatives for two days of presentations and discussion at the fifth annual workshop on Enabling Technologies for Alzheimer's Disease Research.
APP and Axonal Transport: A Report from Bar Harbor
It is widely accepted that at least a fraction of APP is actively transported along the axon to the nerve terminal and does not return to the cell body.
BBB/Brain Vasculature: A Report from Bar Harbor
After release, some Aβ is degraded locally, a second fraction leaves the brain through interstitial fluid drainage and along brain arterioles, while another fraction is actively transported by proteins, such as LRP and glycoprotein-P, across the blood-brain barrier (BBB) into systemic circulation.
Aging and AD: A Report from Bar Harbor
Clearly, the greatest risk factor for AD is advanced age, but a satisfying explanation of the link between aging and AD remains uncertain. To understand this connection, it is argued that a better understanding of "normal" aging is needed.
Enabling Technologies: A Report from Bar Harbor
This workshop has an enduring interest in facilitating the import into AD research of new technologies developed in other areas. This year an approach was presented that makes it possible to watch neurons grow and change over time inside living mice.
Recommendations: A Report from Bar Harbor
Recommendations for future research following the Enabling Technologies for Alzheimer's Disease Workshop in Bar Harbor, ME