Jobs
Unlocking the role of α-synuclein co-pathology in neurodegenerative diseases causing dementia using fluid biomarkers and integrative modelling
Posted 02 Dec 2024
Employer
University of Toronto
Location
Toronto, Ontario, Canada
Principal Investigator
Contact
Description
The Tartaglia Lab is seeking a highly motivated and energetic postdoctoral research fellow to support research efforts aimed at deciphering the effect of co-pathology in neurodegenerative diseases. The position will be based in the Centre for Research in Neurodegenerative Diseases at the University of Toronto. The lab utilizes a multimodal approach that includes both imaging and biofluids for biomarker discovery to facilitate early detection of proteinopathies including amyloid, tau, α-synuclein and TDP-43. The candidate will work with a multidisciplinary team at the Centre for Research in Neurodegenerative Diseases, which brings together world-class researchers and clinicians whose mission is to understand neurodegenerative diseases with the ultimate goal of the development and translation of new treatments. The position is partially funded by the Michael J. Fox Foundation.
Key responsibilities:
- Perform laboratory experiments for analysis of biomarkers of neurodegeneration and inflammation using various assays (e.g., antibody-based assays such as ELISA and electrochemiluminescence, single-molecule arrays, determination of total protein/protein concentration, enzyme activity assays, cell-based assays, quantitative PCR).
- Perform technical tasks in the conduct of in vivo research studies.
- Assist in processing of biofluid samples for analysis.
- Prepare, collect, and record research data and specimens in compliance with applicable regulations and SOPs:this includes check and standardize reagents, review protocols, method development and validation of assays, conduct equipment maintenance, enter and verify data, write and revise standard operating procedures, respond to quality assurance audits.
- Ability to troubleshoot effectively and solve scientific problems with moderate supervision.
- Ability to find, read, and understand relevant scientific literature.
- Maintain familiarity with scientific literature and applies knowledge to research projects.
- Contribute to general laboratory maintenance.
- Analyze data, maintain a detailed research record, and draw conclusions regarding presented material and nature of work.
- Attend laboratory meetings, present data, and participates in discussions.
- Co-author research publications and present research at conferences.
- Maintain the physical environment of the lab and a safe research environment.
- Assist in training and mentoring of other laboratory personnel such as graduate students.
- Experience with proteomics an asset..
Requirements
Applicants must have a Ph.D. in neuroscience or other scientific disciplines in a related field. Knowledge and understanding of histology, molecular biology, immunology, and biochemical techniques is a plus. Strong analytical and computer skills are required, including proficiency with basic data analysis programs (Excel, Graph Pad Prism, etc.) and application of statistics. A track record of publication in English language journals. Applicants must demonstrate the potential ability to perform the essential functions of the job as outlined in the position description.
- The ideal candidate should have strong communication skills (both verbal and written) and interpersonal skills to communicate objectives and results.
- Strong collaboration skills are expected.