Jobs

Postdoctoral fellow in Alzheimer’s Disease of functional genomics and human iPSC and chimeric modeling

Posted 14 Feb 2025

Employer

Boston University

Location

Boston, Massachusetts

Principal Investigator

Julia TCW

Contact

Application documents

Cover letter (required), CV with reference contact (required), major publications (optional), indicate your interest on projects under Any comments section or on the cover letter.
Submit the package to juliatcw@bu.edu

Three reference letters should be directly sent to the contacts below.

Contact, or any inquiry

Dr. Julia TCW, Assistant Professor and Director at juliatcw@bu.edu

Description

BU has two positions available:

Postdoctoral associate in Alzheimer’s Disease (AD) iPSC modeling and stem cell therapeutics

Immediately available, multiple NIH funded, private foundation funded

The TCW laboratory in the Department of Pharmacology, Physiology & Biophysics at Boston University Chobanian & Avedisian School of Medicine in Boston is looking for highly motivated and skilled molecular and stem cell biologists to be the drivers of its efforts to translate the genetics of human AD toward therapeutic interventions.

The core program is to translate AD genetics and functional genomics into human brain cells both in vitro 2D and 3D models using human induced pluripotent stem cells (hiPSCs) from population and isogenic lines generated by CRISPR/Cas9 genome editing and in vivo hiPSC/rodent chimera systems in comparison with postmortem brain. In particular, the research will focus on deciphering the molecular mechanism of major AD risk variants as well as protective variants, associated genes and identifying targeted therapeutics. Furthermore, the research focusing on human iPSC-glial transplantation in AD animal models will enable potential stem cell therapeutics. The candidate will join a multidisciplinary and highly collaborative research team that includes computational geneticists, neuroscientists and pharmacologists in the department as well as Genome Science Institute and Center for Systems Neuroscience at Boston University.

Benefits

• Competitive salary commensurate with benefits.
• Access to state-of-the-art computational resources and laboratory facilities.
• Opportunities for professional development, including attending conferences and workshops.
• Collaborative and stimulating research environment with mentorship from experienced scientists and experimental wet lab.
• Potential for career advancement and transition to independent research positions.

Requirements

Eligibility

• Ph.D. in stem cell or neuroscience

Preferred skill set

• Stem cell (mouse or human iPSCs, embryonic stem cells) cultures and any cell type differentiation (2D or 3D cell cultures)
• Or, genome editing, CRISPRa/i screen
• Clear written and oral communication and detailed documentation skills