Jobs
Postdoctoral Fellow
Posted 23 Mar 2024
Employer
Johns Hopkins University School of Medicine
Location
Baltimore, Maryland
Principal Investigator
Contact
To apply, please send a statement of research experience and career goals, a copy of current Curriculum Vitae, and contact information for two or three references to Alyssa Coyne, Ph.D., at acoyne3@jhmi.edu.
Description
The Coyne lab at Johns Hopkins University School of Medicine is seeking a motivated postdoctoral research fellow to investigate the mechanisms and therapeutic targeting of repeat RNA mediated toxicity in C9orf72 ALS/FTD.
The lab has recently demonstrated that pathologic C9orf72 repeat RNA expression damages the nuclear pore complex and compromises neuronal survival in iPSNs. Interestingly, despite similar disruptions of the nuclear pore complex, only antisense, but not sense, repeat RNA expression compromises TDP-43 nuclear function and localization in C9orf72 iPSNs.
The lab is seeking a postdoctoral research fellow to lead studies focused on investigating the discrepant molecular mechanisms by which sense versus antisense repeat RNA initiates nuclear pore complex disruption in C9orf72 ALS/FTD. This project utilizes iPSC derived neurons and postmortem tissues as well as in vitro (recombinant protein, synthetic RNAs) strategies. In addition, we are actively engaged in active collaborative efforts to therapeutically target sense and antisense repeat RNAs. Thus, this project represents an opportunity to perform fundamental mechanistic disease research and gain exposure to industry via our collaborative efforts.
Requirements
Candidates should have a doctoral degree and strong research background. Positions are fully funded for two to three years and opportunities for fellowship grant writing will be encouraged and supported. We encourage individuals from diverse backgrounds to apply. Candidates can start at any time.