Accepts donations from U.K. residents with MS or other conditions, and healthy volunteers who register with the bank. Donors must have longitudinal and/or clinical/medical records. Phenotypes collected include multiple system atrophy, progressive supranuclear palsy, multiple sclerosis, and brain tumors. The bank collects tissues and fluid from the entire brain and spinal cord, a sample of postmortem CSF, a small sample of muscle from the back, and a limited number of muscle, pituitary and pineal glands, and gut samples. Tissues can be fixed, frozen, block, stained, free for cell culture, DNA, RNA. All requests must be approved by an independent panel of experts and lay people. Priority is given to MS and PD studies.