Antibody

Tyrosine Hydroxylase

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Clonality: polyclonal
Host: Rabbit
Source: Chemicon and Upstate are Millipore
Cat# AB152
References:
Morawski, 2010
Heneka, 2010
Paleologou, 2010
Kitada, 2007
Yamaguchi, 2007
Formulation: liquid, Ig, affinity purified, HEPES, BSA, glycerol
Reactivity:
Reacts in: Mammal (various)
many non-mammalian

Immunogen/Epitope

immunogen = denatured tyrosine hydroxylase from rat pheochromo cytoma

Specificity

reacts with tyrosine hydroxylase; ~62 kDa by WB;not on paraffin embedded human tissue

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References

Paper Citations

  1. Morawski M, Brückner G, Jäger C, Seeger G, Arendt T. Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease. Neuroscience. 2010 Sep 1;169(3):1347-63. PubMed.
  2. Heneka MT, Nadrigny F, Regen T, Martinez-Hernandez A, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J, Kirchhoff F, Hanisch UK, Kummer MP. Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6058-63. PubMed.
  3. Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, Zweckstetter M, Masliah E, Lashuel HA. Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci. 2010 Mar 3;30(9):3184-98. PubMed.
  4. Kitada T, Pisani A, Porter DR, Yamaguchi H, Tscherter A, Martella G, Bonsi P, Zhang C, Pothos EN, Shen J. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11441-6. PubMed.
  5. Yamaguchi H, Shen J. Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Mol Neurodegener. 2007;2:10. PubMed.

Further Reading

No Available Further Reading