Antibody

Tau, truncated at Asp421 (C3)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: TauC3
(Vincent L. Cryns, Cell Death Regulation Laboratory, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Chicago, IL)
Research paper
Reference:
Alonso, 2010
Formulation: purified IgG, HEPES, saline, glycerol.
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen = KLH- C S S T G S I D M V D, corresp. to residues 412-421 at the C-terminus of tau truncated at Asp421

Specificity

recognizes tau when truncated at Asp421; no reaction with full-length tau, or with tau truncated at Glu391 or Ala429

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References

Paper Citations

  1. Alonso AD, Di Clerico J, Li B, Corbo CP, Alaniz ME, Grundke-Iqbal I, Iqbal K. Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration. J Biol Chem. 2010 Oct 1;285(40):30851-60. PubMed.

External Citations

  1. paper

Further Reading

No Available Further Reading