Antibody

Tau, total (TAU-5)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Chemicon and Upstate are Millipore
Cat# MAB361
References:
Demars, 2010
Ohsawa, 2008
Wilcock, 2008
Formulation: liquid, ascites
Reactivity:
Reacts in: Bovine, Sheep, Human, Mouse, Rat
other species not tested

Immunogen/Epitope

immunogen = Bovine tau; epitope aa 210-241

Specificity

tau (phosphorylated and non-phosphorylated isoforms); stains neurofibrillary tangles, neuropil threads and neuritic plaques associated with AD; no cross-reactivity with tubulin or other microtubule proteins

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References

Paper Citations

  1. Demars M, Hu YS, Gadadhar A, Lazarov O. Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice. J Neurosci Res. 2010 Aug 1;88(10):2103-17. PubMed.
  2. Ohsawa I, Nishimaki K, Murakami Y, Suzuki Y, Ishikawa M, Ohta S. Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. J Neurosci. 2008 Jun 11;28(24):6239-49. PubMed.
  3. Wilcock DM, Lewis MR, Van Nostrand WE, Davis J, Previti ML, Gharkholonarehe N, Vitek MP, Colton CA. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci. 2008 Feb 13;28(7):1537-45. PubMed.

Further Reading

No Available Further Reading