Antibody
Tau (TAU-5)
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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Lab Vision Thermo Scientific
Cat# MS-247
References:
Adams, 2009
Yuzawa, 2008
Formulation: ascites, protein-G, PBS, with or w/o BSA and azide, and as Biotin conj.
Reactivity:
Reacts in: Cow, Sheep, Human, Mouse, Rat
Immunogen/Epitope
immunogen = bovine MAPs (epitope sequence in the middle of tau)
Specificity
45-68 kDa tau, phos. or non-phos., in neurofibrillary tangles, neuropil threads, neuritic plaques, astrocytes and ribosomes, not other MAPs or tubulin
References
Paper Citations
- Adams SJ, Crook RJ, Deture M, Randle SJ, Innes AE, Yu XZ, Lin WL, Dugger BN, McBride M, Hutton M, Dickson DW, McGowan E. Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration. Am J Pathol. 2009 Oct;175(4):1598-609. PubMed.
- Yuzwa SA, Macauley MS, Heinonen JE, Shan X, Dennis RJ, He Y, Whitworth GE, Stubbs KA, McEachern EJ, Davies GJ, Vocadlo DJ. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol. 2008 Aug;4(8):483-90. PubMed.
Further Reading
No Available Further Reading
Comments / Questions
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