Antibody

Tau (TAU-5)

Tools

Back to the Top

Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Biosource Invitrogen
Cat# AHB0042
References:
Bhaskar K, 2010
Ittner, 2010
Clavaguera, 2009
Nicholson, 2009
Chu, 2009
Lesne, 2005
Formulation: ascites, affinity purified BSA, azide, unconj.
Reactivity:
Reacts in: Cow, Sheep, Human, Mouse, Rat
others not tested

Immunogen/Epitope

immunogen = purified bovine microtuble associated proteins; epitope in middle region of tau

Specificity

tau proteins ranging from 45-68 kDa, not other MAPs or tubulin; tangles marker; reacts with non-phosphor. and phosphor. tau

Comments / Questions

No Available Comments

Make a comment or submit a question

To make a comment you must login or register.

References

Paper Citations

  1. Bhaskar K, Konerth M, Kokiko-Cochran ON, Cardona A, Ransohoff RM, Lamb BT. Regulation of tau pathology by the microglial fractalkine receptor. Neuron. 2010 Oct 6;68(1):19-31. PubMed.
  2. Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, Wölfing H, Chieng BC, Christie MJ, Napier IA, Eckert A, Staufenbiel M, Hardeman E, Götz J. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. 2010 Aug 6;142(3):387-97. Epub 2010 Jul 22 PubMed.
  3. Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M, Tolnay M. Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol. 2009 Jul;11(7):909-13. PubMed.
  4. Nicholson AM, Ferreira A. Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity. J Neurosci. 2009 Apr 8;29(14):4640-51. PubMed.
  5. Chu J, Hong NA, Masuda CA, Jenkins BV, Nelms KA, Goodnow CC, Glynne RJ, Wu H, Masliah E, Joazeiro CA, Kay SA. A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2097-103. PubMed.
  6. Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH. A specific amyloid-beta protein assembly in the brain impairs memory. Nature. 2006 Mar 16;440(7082):352-7. PubMed. RETRACTED

Further Reading

No Available Further Reading