Antibody

Tau phos Ser409 (PG5)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG3
Source: Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org.
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

immunogen = the synthetic phosphopeptides KSPRHLS(P)NV S(P)STGS(P)ID and KSPRHLS(P)NV SS(P)TGSID

Specificity

recognizes the PKA-dependent phosphorylation of ser409 in tau; immunoreactivity with neurofibrillary pathology in both early and advanced Alzheimer’s disease, but not in normal brain tissue; reacts with only PHF and the tau peptide containing phospho ser409

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References

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Further Reading

Papers

  1. Vingtdeux V, Davies P, Dickson DW, Marambaud P. AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies. Acta Neuropathol. 2011 Mar;121(3):337-49. PubMed.