Clonality: monoclonal
Host: Mouse
Source: 11A5
(Tamie Chilcote, ActiveSite Pharmaceuticals, San Francisco, CA)
Reference:
Paleologou, 2010
Reactivity:
Reacts in: Human
<a href="http://www.jbc.org/content/281/40/29739.full" target="_new">Paper</a>, Anderson et al., 2006

Immunogen/Epitope

immunogen = the peptide CAYEMPSEEGYQ, corresp. to aa 124-134, with a phosphorylated Serine 129 and a Cys residue added at the N terminus for coupling

Specificity

detects α-synuclein phosphotylated at Serine 129

Comments / Questions

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References

Paper Citations

1. Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, Zweckstetter M, Masliah E, Lashuel HA. Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci. 2010 Mar 3;30(9):3184-98. PubMed.

Other Citations

1. Tamie Chilcote

External Citations

1. Paper

Further Reading

No Available Further Reading