Clonality: polyclonal
Host: Rabbit
Source: PS1_NT
(Gopal Thinakaran, Department of Neurobiology, University of Chicago)
References:
Veeraraghavalu, 2010
O'Connor, 2008
Ikeuchi, 2003
Reactivity:
reference: <a href="http://www.sciencedirect.com/science?_ob=MImg&amp;_imagekey=B6WSS-41838X3-M-1&amp;_cdi=7054&amp;_user=10&amp;_pii=S0896627300802913&amp;_coverDate=07%2F31%2F1996&amp;_sk=%23TOC%237054%231996%23999829998%23575399%23FLA%23display%23Volume_17,_Issue_1,_Pages_1-192_%28July_1996%29%23tagged%23Volume%23first%3D17%23Issue%23first%3D1%23date%23%28July_1996%29%23&amp;view=c&amp;_gw=y&amp;wchp=dGLbVzb-zSkWA&amp;md5=9d1eb94a660d8463a11102f283974603&amp;ie=/sdarticle.pdf" target="_new">Thinakaran G., et al.</a>, Neuron 1996 Jul; 17(1):181-90

Immunogen/Epitope

(epitope contains residues 1–65 of the N-terminus of PS1)

Specificity

full-length PS1 and NH2-terminal fragment of PS1

Comments / Questions

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References

Paper Citations

1. Veeraraghavalu K, Choi SH, Zhang X, Sisodia SS. Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling. J Neurosci. 2010 May 19;30(20):6903-15. PubMed.
2. O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, Vassar R. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 2008 Dec 26;60(6):988-1009. PubMed.
3. Ikeuchi T, Sisodia SS. The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage. J Biol Chem. 2003 Mar 7;278(10):7751-4. Epub 2003 Jan 24 PubMed.

External Citations

1. Gopal Thinakaran
2. Thinakaran G., et al.

Further Reading

No Available Further Reading