Clonality: polyclonal
Host: Rabbit
Source: anti-αPS1 Loop
(Gopal Thinakaran, Department of Neurobiology, University of Chicago)
References:
Veeraraghavalu, 2010
Yu, 2001
Luo, 2003
Reactivity:
Reacts in: Human, Mouse
reference: <a href="http://www.jbc.org/content/272/45/28415.full" target="_new">Thinakaran G., et al.</a>, J Biol Chem 272:28415-28422, l997

Immunogen/Epitope

immunogen = aa 320-375 of human PS1

Specificity

reacts with epitopes in the hydrophilic loop domain (amino acids 263–407) of human and mouse PS1; no cross reactivity of PS1Loop antiserum with the human PS2 fusion protein

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References

Paper Citations

1. Veeraraghavalu K, Choi SH, Zhang X, Sisodia SS. Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling. J Neurosci. 2010 May 19;30(20):6903-15. PubMed.
2. Yu H, Saura CA, Choi SY, Sun LD, Yang X, Handler M, Kawarabayashi T, Younkin L, Fedeles B, Wilson MA, Younkin S, Kandel ER, Kirkwood A, Shen J. APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron. 2001 Sep 13;31(5):713-26. PubMed.
3. Luo WJ, Wang H, Li H, Kim BS, Shah S, Lee HJ, Thinakaran G, Kim TW, Yu G, Xu H. PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. J Biol Chem. 2003 Mar 7;278(10):7850-4. Epub 2003 Jan 8 PubMed.

External Citations

1. Gopal Thinakaran
2. Thinakaran G., et al.

Further Reading

No Available Further Reading