Clonality: polyclonal
Host: Rabbit
Source: Wako Chemicals
Cat# 016-20001
References:
Lewis TL, 2010
Mildner, 2008
Formulation: sera, affinity purified, TBS, no preservatives or stabilizers
Reactivity:
Reacts in: Human, Mouse, Rat

Immunogen/Epitope

Immunogen = synthetic peptide corresponding to the C-terminus of Iba-1 (Ionized calcium binding adaptor molecule 1)

Specificity

Microglia and macrophages, but no cross reactivity with neurons and astrocytes

Comments / Questions

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References

Paper Citations

1. Lewis TL, Cao D, Lu H, Mans RA, Su YR, Jungbauer L, Linton MF, Fazio S, LaDu MJ, Li L. Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease. J Biol Chem. 2010 Nov 19;285(47):36958-68. Epub 2010 Sep 16 PubMed.
2. Mildner A, Schmidt H, Nitsche M, Merkler D, Hanisch UK, Mack M, Heikenwalder M, Brück W, Priller J, Prinz M. Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat Neurosci. 2007 Dec;10(12):1544-53. PubMed.

Further Reading

No Available Further Reading