Antibody

CREB phos Ser133

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Clonality: polyclonal
Host: Rabbit
Isotype: IgG
Source: Upstate and Chemicon are Millipore
Cat# 06-519
References:
Puzzo, 2009
Trinchese, 2008
Formulation: liquid, PBS, BSA, azide, Protein A/affinity purified
Reactivity:
Reacts in: Human, Hamster, Mouse, Rat

Immunogen/Epitope

Immunogen = synthetic phospho-peptide corresponding to residues 123-136 of rat CREB coupled to KLH

Specificity

recognizes 43 kDa CREB phosphorylated at Ser133. May also recognize phosphorylated CREM (p30) and ATF-1 (p38)

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References

Paper Citations

  1. Puzzo D, Staniszewski A, Deng SX, Privitera L, Leznik E, Liu S, Zhang H, Feng Y, Palmeri A, Landry DW, Arancio O. Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model. J Neurosci. 2009 Jun 24;29(25):8075-86. PubMed.
  2. Trinchese F, Fa' M, Liu S, Zhang H, Hidalgo A, Schmidt SD, Yamaguchi H, Yoshii N, Mathews PM, Nixon RA, Arancio O. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest. 2008 Aug;118(8):2796-807. PubMed.

Further Reading

No Available Further Reading