Antibody

APP or β-Amyloid (6E10)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: BioLegend
Cat# 803004 (25 µl), RRID AB_2715854
Cat# 803001 (200 µl), RRID AB_2564653
Cat# 803002 (500 µl), RRID AB_2564654
Cat# 803003 (1 ml), RRID AB_2564652
Previously Covance Catalog# SIG-39320
Formulation: Purified by affinity chromatography. PBS, no preservatives or carrier proteins.
Reactivity:
Reacts in: Human
Availability: Available from BioLegend

Immunogen/Epitope

epitope lies within amino acids 3-8 of beta amyloid (EFRHDS)

Specificity

reactive to aa 1-16 Aβ and to APP; reacts to the abnormally processed isoforms, as well as precursor forms

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References

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Further Reading

Papers

  1. Sloane JA, Pietropaolo MF, Rosene DL, Moss MB, Peters A, Kemper T, Abraham CR. Lack of correlation between plaque burden and cognition in the aged monkey. Acta Neuropathol. 1997 Nov;94(5):471-8. PubMed.
  2. Kraszpulski M, Soininen H, Riekkinen P Sr, Alafuzoff I. Pitfalls in the quantitative estimation of beta-amyloid immunoreactivity in human brain tissue. Histochem Cell Biol. 1998 Oct;110(4):439-45. PubMed.
  3. Wisniewski HM, Sadowski M, Jakubowska-Sadowska K, Tarnawski M, Wegiel J. Diffuse, lake-like amyloid-beta deposits in the parvopyramidal layer of the presubiculum in Alzheimer disease. J Neuropathol Exp Neurol. 1998 Jul;57(7):674-83. PubMed.