Antibody

APP

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Clonality: polyclonal
Host: Goat
Source: Biosource Invitrogen
Cat# AHB0131
References:
( Lewis TL, 2010, but see also Invitrogen C-terminus antibody 36-6900 )
Liu, 2007
Formulation: liquid, whole serum, azide, unconj.
Reactivity:
Reacts in: Human
others not tested

Immunogen/Epitope

immunogen = synthetic peptide (G Y E N P T Y K F F E Q M Q N) corresp. to aa sequence 681-695 of C terminus of human APP

Specificity

C-terminus of APP(100kDa), may cross-react with APLP2

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References

Paper Citations

  1. Lewis TL, Cao D, Lu H, Mans RA, Su YR, Jungbauer L, Linton MF, Fazio S, LaDu MJ, Li L. Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease. J Biol Chem. 2010 Nov 19;285(47):36958-68. Epub 2010 Sep 16 PubMed.
  2. Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G. Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron. 2007 Oct 4;56(1):66-78. PubMed.

Further Reading