Clonality: polyclonal
Host: Unknown Host
Source: APP B5 (5313)
(Christian Haass, Ludwig-Maximilians-Universität München, Munich, Germany
Paper, Steiner et al.
References:
Kuhn, 2010
Stamer, 2002
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen = a sequence in the ectodomain, aa 444-592, of human APP

Specificity

reactive with APPs, ectodomain

Comments / Questions

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References

Paper Citations

1. Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Rossner S, Lichtenthaler SF. ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. EMBO J. 2010 Sep 1;29(17):3020-32. PubMed.
2. Stamer K, Vogel R, Thies E, Mandelkow E, Mandelkow EM. Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol. 2002 Mar 18;156(6):1051-63. PubMed.

External Citations

1. Christian Haass
2. Paper

Further Reading