Clonality: polyclonal
Host: Rabbit
Source: CT15
(S Soriano, 2001
Paper, JBC online,
Dr. Edward Koo, University of California, San Diego),
References:
Lee, S, 2010
Banwait, 2008
Rockenstein, 2007
Galvan, 2006
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

immunogen = synthetic
peptide corresp. to the C-terminal 15 residues of APP (aa 680-695)

Specificity

APP C-terminal fragments; recognizes the last 15 COOH-terminal amino acid residues of APP₆₉₅

Comments / Questions

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References

Paper Citations

1. Lee S, Varvel NH, Konerth ME, Xu G, Cardona AE, Ransohoff RM, Lamb BT. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. Am J Pathol. 2010 Nov;177(5):2549-62. PubMed.
2. Banwait S, Galvan V, Zhang J, Gorostiza OF, Ataie M, Huang W, Crippen D, Koo EH, Bredesen DE. C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. J Alzheimers Dis. 2008 Feb;13(1):1-16. PubMed.
3. Rockenstein E, Torrance M, Adame A, Mante M, Bar-On P, Rose JB, Crews L, Masliah E. Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation. J Neurosci. 2007 Feb 21;27(8):1981-91. PubMed.
4. Galvan V, Gorostiza OF, Banwait S, Ataie M, Logvinova AV, Sitaraman S, Carlson E, Sagi SA, Chevallier N, Jin K, Greenberg DA, Bredesen DE. Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7130-5. PubMed.

External Citations

1. Paper, JBC online
2. Dr. Edward Koo

Further Reading

No Available Further Reading