AlzBiomarker

Amyotrophic Lateral Sclerosis vs Alzheimer's Disease: Aβ42 (CSF)

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Meta-analysis of four studies showed that levels of Aβ42 in the cerebrospinal fluid are nearly 70 percent higher in people with amyotrophic lateral sclerosis than in people with Alzheimer's disease (effect size = 1.665, p = 0.0001). For context, our meta-analysis of  more than 200 comparisons found that the levels of CSF Aβ42 in control subjects are  about 80 percent higher than in people with Alzheimer’s disease.

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How to interpret a forest plot: Each individual effect size (ES) is a ratio of the mean biomarker level in one condition over the mean level in another condition. An ES equal to 1 means that the two conditions had identical mean values. An ES > 1 indicates higher levels in the first condition, whereas an ES < 1 indicates lower levels in the first condition. The overall ES, indicated by a black diamond, is a weighted average of the individual effect sizes. The weight of each data point was determined by the inverse of the variance and is reflected in the size of each square. The width of the overall ES diamond is determined by the 95 percent confidence interval. Data out of range of the scale, including ES and confidence intervals, are indicated by an arrowhead at the edge of the plot, when applicable. 

Version 3.0, July 2021.