Controlling Blood Pressure May Lower Amyloid in ApoE4 Carriers
Scientists report that reducing hypertension may ward off amyloid pathology in people who have the ε4 version of the ApoE gene...
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Lilly Halts Phase 2 Trial of BACE Inhibitor Due to Liver Toxicity
Eli Lilly and Company announced yesterday that they have terminated the Phase 2 trial of their BACE inhibitor LY2886721 due to liver abnormalities.
Immune Cell Receptor Gives Aβ a Toxic Edge
Despite ample evidence implicating Aβ in Alzheimer’s pathology, scientists still struggle to understand how the peptide harms the brain.
AD Trial Simulation Tool Receives Regulators’ Blessings
The FDA and EMA have endorsed a new tool for modeling AD clinical trials to select the best design, potentially speeding up drug discovery.
Neural Activity Tips Endosomal Balance, Hastens Amyloid Pathology
Neural activity sends amyloid precursor proteins into endosomes where β-secretase drives Alzheimer pathology.
Studies Suggest Mitochondria Changes Precede Aging, Alzheimer’s
Studies support the idea that mitochondrial changes drive aging and AD pathogenesis.
Immune Receptor Binds Aβ Oligomers, Spurs Synaptic Loss
New research proposes a neuroimmune receptor as the latest Aβ binding partner.
Tau Tracer May Light Up All Tauopathies
The first report on PBB3, the latest tau ligand for brain imaging under development, suggests it binds all types of tau aggregate.
LOADed ADAM 10 Mutations Bolster Amyloid Hypothesis
Rare mutations in the ADAM10 gene make a genetic case for the amyloid cascade as a cause of late onset Alzheimer's disease.
Spastin Leads to Severed Microtubules in Tau-Filled Dendrites
A new study proposes microtubule-chopping enzymes as the missing link in the cascade of pathology leading from Aβ to tau to neuronal death.
Shutdown Grabs Headlines, but Sequestration Does Real Damage
As NIH researchers are preparing to return to their laboratories, Alzheimer's researchers warn about the greater consequences of cutting already limited resources.
Functional MRI Detects Brain Abnormalities in Former Football Players
Functional neuroimaging scans can pick up stark neural abnormalities in football players with repeated head injuries before their cognition drops much in executive function tests.
Protein Disrupts Aβ–Prion Tryst, Blocks Aβ Toxicity
An astrocyte protein stymies toxic interplay between Aβ oligomers and prion proteins.
More Evidence for AD Starting Without Brain Amyloid
People with neurodegeneration but not brain amyloid surface in two new studies of preclinical AD, suggesting this odd population is both legitimate and potentially large.
Averting a Late-life Crisis: Midlife ApoE2 Clears Plaques in Mice
Changing ApoE levels in midlife influences Aβ pathology in mice, supporting an ApoE-oriented therapeutic strategy in Alzheimer’s disease.
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