Total Recall—Age, Genetic Variation, and Memory
“Use it or lose it,” a common mantra in the Alzheimer disease community, stems from studies that suggest the brain is analogous to muscle...
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Inclusions Restrain Sinister Synphilin—Doppelgänger Implicated in Parkinson Disease
An ominous double may be at work in Parkinson disease (PD) and other neurodegenerative diseases...
“Morris Land Maze” Reveals Early Loss of Spatial Memory in MCI
Alzheimer disease brings on a tendency to wander, and patients sometimes become disoriented even in the most familiar surroundings...
Movie Alert: Acclaimed Film About Early-onset AD Debuts in New York
No eye-popping action scenes, no happy ending...
Affibodies—Putting the β in Aβ?
Aβ is infamous for its ability to form large fibrils rich in β-sheet secondary structure...
Transgenics Galore: Choking Apoptosis Rescues Triple AD Pathologies
Overexpressing a single anti-apoptotic protein on top of an already triple-transgenic model of Alzheimer disease (AD) rescues amyloid and tau pathology...
Immunotherapy: Old Dogs, New Tricks
Enlisting the immune system to fight Alzheimer disease can take the form of immunization against Aβ, or other attempts to modulate the inflammatory response that plays a role in disease...
Cystatin C’s Naughty Side—Slowing Aβ Degradation by Cathepsin B
Scientists have boosted the activity of an Aβ-degrading enzyme by reducing levels of an endogenous inhibitor...
Nuclear Pore Complexes Built to Last, But Not Forever
Whether you’re a job seeker or a postmitotic cell, it’s not a good idea to burn your bridges...
Rapid Case of ALS Claims Sean Forrester Scott, 1969-2009
The battle against ALS lost a soldier Monday when Sean Forrester Scott died in his sleep from complications of the disease...
Divorce Protein Style—APP Fragments Go Their Own Way in Cells
Full-length APP has been suggested to be an adaptor protein that links vesicles to the kinesin motors that power microtubule-mediated transport out to axons, but a new study may be cause to revise that model...
Peripheral p75 Protects Against Aβ Toxicity
The cell surface receptor p75 has earned something of a bad boy reputation among Alzheimer disease (AD) researchers...
Aβ Immunotherapy—Muscling in on Inclusion Body Myositis
Amyloid-β (Aβ) oligomers are presumed guilty of killing neurons in Alzheimer disease, but that may not be their only transgression...
New Triple Transgenic Shows Mitochondrial Damage by Tau, Aβ
A new mouse model of combined Aβ and tau pathology reveals that the pair deliver a one-two punch to mitochondria...
New Retro: Mouse Gene Tweaks Both Aβ, Tau Pathology via GSK3
Researchers have identified an unusual gene that keeps a lid on both amyloid production and tau phosphorylation in mouse brain...
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