Stayin’ Alive—Huge Study Quickens Quest for Plasma AD Biomarker
Identifying people on the verge of dementia before they actually succumb has become somewhat of a Holy Grail for Alzheimer disease research...
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Wingless Pathway Helps Tauopathy Take Off
The microtubule-associated protein tau is the major component of the intracellular neurofibrillary tangles (NFT) found in patients with various neurodegenerative disorders, including Alzheimer's and frontotemporal dementia. Scientists know that hyperphosphorylation of tau is at the root of its pathology, but...
Lessons From the Lipidome—PLA2 Linked to AD Pathology
The genome, the proteome, and the transcriptome have all been successfully trawled for links to AD...
Mnemonic Models—Flies, Mice, and Rats Reveal Pathways to Memory
<em>Drosophila</em> have proven a valuable tool for studies of biochemical pathways related to memory and to neurodegenerative disease...
Transgenic Mice Accumulate Human Tau in Degenerating Hippocampal Neurons
The question of how neurofibrillary tangles (NFTs) contribute to the profound loss of neurons in Alzheimer's disease remains unsettled in part because of a dearth of suitable animal models...
News on the Molecular Biology of Aging
P53 misregulation and cancer have become almost synonymous in the scientist's imagination. Mutations in this prominent tumor suppressor gene have been found in the majority of human cancers...
Down and In—the Location of Amyloid-β Does Matter
Though the roles of the Aβ peptide and AβPP in the pathology of Alzheimer's disease have been well studied, many questions remain to be answered, not least being cause and effect—are plaques the root or the result of the problem?...
World Alzheimer Conference 2000: Pin1 Binds Both Tau and APP
One of the great unsolved mysteries of Alzheimer's disease is the link between the disease's two major lesions: β amyloid plaques and tau tangles...
Mouse Genome Mapped
Members of the International Mouse Genome Consortium reported this week that they have succeeded in making a physical map of this rodent’s genome using, ironically, the sequence of the human genome as a template....
Oxidative Stress Triggers Neuronal Cell-Cycle Reentry
Researchers from The Jackson Laboratory and Tufts University report that oxidative stress is linked to cell-cycle re-entry and neurodegeneration in a mouse expressing abnormally low levels of the apoptosis-inducing factor (Aif) gene...
Nicastrin Mutations Selectively Modulate Notch Processing
Worries over side effects of γ-secretase inhibitors due to their unwanted effect on Notch cleavage might ease a little with a report demonstrating that the two cleavage events may be regulated at least partly independently. Certain nicastrin mutations affect only Notch cleavage, not AβPP cleavage.
MRI Keeps an Eye on Those Transplanted Stem Cells In Vivo
Embryonic stem (ES) cells have the inherent potential to replace or repair almost every tissue in the body. One key to this prowess is the ability to migrate...
Focal Adhesion Proteins: Is this How Amyloid Causes Dystrophic Neurites?
Research by Jorge Busciglio's lab suggests that focal adhesion (FA) proteins may be critical elements in the production of dystrophic neurites in Alzheimer's disease.
Cholesterol Continued: CYP46 Gene Linked to AD, ApoE
In this week's issue of the Archives of Neurology, collaborators from around Europe propose that a polymorphism in the gene for cholesterol 24-hydroxylase CYP46) is a risk factor for late-onset Alzheimer's...
Behold the Power of Cheese
Make that "blue cheese," a massive protein that is expressed in the CNS of <em>Drosophila</em>. In tomorrow’s Journal of Neuroscience, researchers report that <em>blue cheese</em> mutations are involved in progressive neurodegeneration and the accumulation of protein aggregates...
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