Solanezumab Selected for Alzheimer’s A4 Prevention Trial
Researchers announced the selection of solanezumab as the first therapeutic drug to be evaluated in the A4 prevention clinical trial...
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Do Biomarkers Improve Diagnostic Accuracy?
It’s a scenario familiar to many clinicians: A patient diagnosed with mild cognitive impairment asks if he or she will eventually develop Alzheimer’s disease.
GPCRs Implicated in HIV, Parkinson Disease Dementias
Dementia strikes in many forms besides Alzheimer disease, and two recent reports take a look at the biochemical basis for dementias in other settings...
New Assays for Aβ Oligomers—Spinal Fluid a Miss, Brain Awash
Like a blue moon, could oligomeric amyloid-β in the cerebrospinal fluid (CSF) be too rare to be informative?...
Combination Drug Trials: Time to Open a New Front in AD?
Over the past year, chatter has been building about combination drug therapy as the "New New Thing" in Alzheimer’s disease research...
Could Antibodies Against Pyroglutamate Safely Break Down Plaques?
Most Aβ antibodies in development can prevent plaque buildup, but few eliminate existing plaques...
In Pursuit of Toxic Tau
Neurofibrillary tangles of tau protein litter Alzheimer’s disease brains, but are they actually bad for neurons?...
TBPB or Not to Be—The Latest on Muscarinic Receptor Agonists
Key roles in modulating cognition and behavior made the M1 muscarinic acetylcholine receptor (mAChR) a prime target for AD drug developers...
Not So Fast: Amyloid PET Needs More Data Before Insurance Pays
Your health insurance may not cover brain amyloid scans anytime soon...
Orlando Conference: The Chicken and the Egg
Aβ levels and amyloid plaque load can be reduced significantly in animal models of Alzheimer's disease by interfering—either genetically or pharmacologically—with the immunoregulatory molecule CD40 ligand...
Research Brief: Epidemiological Study Links Cancer, AD
People with Alzheimer disease may be less likely to develop cancer, and people with cancer may have a lower risk of AD, according to a large population-based epidemiological study...
Pinning Down Role for Tau Proline Isomers in Alzheimer’s
Identifying phosphorylation sites in culprit proteins and figuring out if they matter for disease progression are no small feats...
Herpes and AD—Virus Hitches Ride with APP
In this month's Aging Cell, researchers show that the herpes simplex virus (HSV), traveling away from the neuronal cell body along axons, is associated with the amyloid precursor protein (APP)...
The Limits of Compensation: Double Loss of Proteases Causes Massive Neuronal Death
Mice lacking both cathepsin B and L, two lysosomal proteases that have been implicated in the development of Alzheimer's disease, suffer a profound loss of neurons soon after birth...
Hearts and Minds: Can Both Benefit From Cholesterol Pathway Fix?
Alzheimer and heart disease share a common cast of villains...
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