Too Little Acetylcholine, Too Much Dopamine Spell Trouble for Neurons
Two new reports this week show what can happen when neurotransmitters get out of whack...
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Prion Protein Keeps β-secretase in Check
Alzheimer disease and the prion diseases share some features, with both conditions...
Keystone: Partners in Crime—Do Aβ and Prion Protein Pummel Plasticity?
Finding Aβ oligomers bound to cellular prion (PrPc) was absolutely unexpected...
Trial Troika—Immunotherapy Interrupted, Lipitor Lags, Dimebon Delivers
A flurry of clinical trial news this past week brought mostly disappointment...
Dietary Toxins and Neurodegenerative Diseases—Guam Revisited
More than 50 years ago, U.S. Navy physicians stationed on Guam found a shocking rate of amyotrophic lateral sclerosis, or ALS—about 50 to 100 times higher than expected. Now, a new paper may revive one of the original ideas: that ingestion of...
Curbing Cell Cycle Re-entry: Window of Opportunity for NSAIDs?
The aberrant re-entry of post-mitotic neurons into the cell cycle is an early event in AD pathology, preceding amyloid deposition...
Presenting: A Not-Quite-Parkinson's Mouse Model
A transgenic mouse overexpressing a mutant human form of α-synuclein develops Lewy body inclusions that cause neurodegeneration and a severe movement disorder, according to report in yesterday's Neuron...
Neurons Need Cholesterol from Glia to Make Synapses
Cholesterol and apolipoproteins in Alzheimer's disease have become a rapidly developing—and sometimes confusing—area of investigation, but most of it suggests that lowering cholesterol might slow disease progression...
Calbindin Study: Is Calcium the Molecular Handle on Dysfunction in AD?
It’s getting hot around calcium. A trend is afoot about something going awry with calcium regulation in Alzheimer neurons, and it makes this ion an increasingly attractive suspect in AD pathogenesis, even if important details remain murky...
Homing in on Roles for PS Complex Proteins APH-1 and PEN-2
Two recent papers from the Journal of Biological Chemistry shed additional light on the roles of APH-1 and PEN-2, two proteins that were only last year identified in screens of the roundworm <em>C. elegans</em> and implicated as members of the presenilin (PS) complex...
Fog Beginning to Clear on Aβ-Degrading Enzymes?
There are two principal ways by which the Aβ accumulation seen in the brains of people with AD can occur. One—overproduction by β- and γ-secretases...
ER Struggles in Motor Neurons That Fall to ALS
Why do only motor neurons fail in ALS when the cause of pathology, such as mutant protein, exists in many different cells?...
Conformation Rules Part 2: News, Common Threads, Debate from San Diego Protein Misfolding Conference
This second meeting report is continued from <a href="/news/conference-coverage/conformation-rules-part-1-news-common-threads-debate-san-diego-conference">Part 1</a>...
Neurogenesis—A Mechanism for Memory Storage, Clearance?
Research presented in the May 27 issue of Neuron supports links between ongoing excitatory activity in the neural networks of the hippocampus and adult neurogenesis...
AICD—Salute to Salutary Effects
Amyloid-β (Aβ) precursor protein (APP) has something of a mixed reputation...
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