Donanemab Approved in the U.S.
The antibody becomes the second amyloid immunotherapy to receive traditional FDA approval, joining Leqembi.
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PET Tracers For Non-Alzheimer’s Tauopathies Enter Clinical Testing
New candidate OXD-2314 binds 3R and 4R forms of tau and has begun Phase 1. The pan-tau tracer APN-1607 begins Phase 3 for progressive supranuclear palsy, a 4R tauopathy.
Remember Amyloid-eta? A Decade Later, News on a Physiological Function
To modulate synapses, Aη weakens ion flux through glutamate receptors and strengthens their non-ionotropic signaling. This dual action is a first, say scientists.
T Cells in the Brain Goad Microglia to Muddle Myelin
In mouse models of amyloidosis, CD8+ T cells trigger myelin pathology by rousing microglia and confusing oligodendrocytes.
Microglial Transplants Reverse Age-Related Pathology in Mice
Mice missing microglia develop astrogliosis and neurodegeneration by middle age. Giving them healthy microglia prevents or reverses pathology.
Toward an AD CRISPR Therapy: Tweaking APP Terminus Cuts Plaque
Nixing an endosomal targeting sequence shields APP from BACE1, reducing Aβ and pathologic C-terminal fragments in mice.
All About Exposure: How to Get Enough Progranulin into the Brain?
Injected into the cerebrospinal fluid, a viral vector delivers the lysosomal protein into the human brain. In mice, a protein transport vehicle delivered into the blood does the same.
Blood May Foretell Parkinson’s Up to Seven Years Prior
A panel of eight plasma proteins identified people who were on the path to Parkinson’s. Could this help select participants for prevention trials?
Donanemab Approval Likely to Pose New Quandaries for Clinicians
With limited guidance, physicians will have to navigate questions about whom to treat, when to stop, and how to manage safety.
World Trade Center Responders at Risk for Early Onset Dementia
People who sifted through piles of debris are nine times likelier to develop early onset, all-cause dementia than those exposed to little toxic dust.
New PET Ligand Captures α-Synuclein in Parkinson’s, MSA Brains
C05-05 binds α-synuclein deposits in the mouse, marmoset, and human brain. Uptake in the PD midbrain correlated with motor symptom severity.
Unanimous: FDA Advisory Committee Backs Donanemab
All 11 committee members voted that the antibody was effective for people with MCI or mild AD dementia, with its benefits outweighing risks.
Microglia Make Tau, Spelling Their Demise in Tauopathies
When carrying a pathogenic tau variant, microglia were bad at phagocytosis, barely made TREM2, and spat out neurotoxic proteins.
Neuron-Glia Crosstalk Underlies Senescence, Impaired Lipid Metabolism
As flies age, mitochondrial damage in their neurons somehow ages glia, which, in turn, cause lipid droplets to pile up on other, healthy glia.
Caught in the Act: Cryo-EM Exposes γ-Secretase Catalytic Pose
The enzyme cleaves off three amino acids at a time with a twist of the substrate, and a helping hand from a β-strand.
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