Miami: Is Human Amyloid Imaging Ready for Clinical Trials?
The 5th HAI conference concluded with a panel discussion of how far amyloid PET has come in the seven years since its first major publication...
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PARK9 Is Unveiled—Mutations Compromise Orphan Lysosomal ATPase
The field of Parkinson disease (PD) genetics has just grown. A paper in the September 10 Nature Genetics online reveals that...
Lysosomes and Proteasomes Compete for PD Researchers' Attention
Look to the lysosome—not the proteasome—for protein degradation gone awry in Parkinson's disease, suggest the authors of an article published in this week’s Science...
First Crystal Structure of Monoclonal Antibody Binding to Aβ
In the September 25 PNAS online, researchers published the first...
Reel World—Viewing Long-Term Changes in Neuron Structure, Activity
Researchers describe a method for capturing time-lapse video of neurons in mouse disease models over a period of months...
Adult Stem Cells Target Inflammation, Replace Cells in MS Model
Stem cells injected into the cerebral ventricles—or even injected intravenously—find their way to sites of inflammation in an animal model of multiple sclerosis (MS), according to a report in today’s Nature...
Adult Neurogenesis—A Win Wnt Situation?
In today’s Nature, researchers report that Wnt signaling plays an important role in...
Kiss and Tell—STED Microscopy Resolves Vesicle Recycling Question
The “kiss-and-run” theory of synaptic vesicle recycling posits that vesicles...
Hypertension Begets Aβ, Begets Cardiovascular Damage
Mounting epidemiological evidence establishing cardiovascular disease as a risk factor for Alzheimer disease...
ALS—Is It the Neurons or the Glia?
One well-characterized cause of amyotrophic lateral sclerosis (ALS) is mutation of the copper-zinc isoform of superoxide dismutase (SOD), causing progressive degeneration of motor neurons. But must these mutations occur in neurons to be detrimental? A report in today’s Science suggests...
Shaping Up Amyloid Toxicity: Does It Compute?
Aggregated proteins lie at the heart of many neurodegenerative diseases, but researchers have struggled to...
Linking APP with Cell Cycle Reentry and Apoptosis—One Kinase Does the Trick
Contentions that activation of the cell cycle and apoptosis at least partly underlie the neurodegeneration seen in Alzheimer's disease (AD) have slowly gained experimental support. Now, a report in the July 30 Journal of Neuroscience suggests that...
More on TGF-β—Can It Protect against AD?
A report in last week's Cell suggests that TGF-β1, one of the three mammalian isoforms of that growth factor, can protect against excitotoxic neurodegeneration...
Aging, Acetate, and Aβ: Sirtuins Regulate Metabolism and More
The extension in lifespan achieved by eating fewer calories depends on activation of sirtuins...
Protein Aggregation In Disease—A New Theory Joins the Fold
Though aggregates of misfolded proteins occur in numerous neurodegenerative disorders,...
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