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In today’s Neuron, scientists at Brigham and Women’s Hospital in Boston, Massachusetts, report that they have devised a biochemical strategy to detect the earliest aggregates of the protein α-synuclein in cultured neurons, mouse brain, and human brain...
Flagging mitochondria, the powerhouses of the cell, have been linked to general aging and also to a variety of neurodegenerative diseases...
You can’t keep a good mitochondrion down. Or maybe you can...
Surprising as it may seem, presenilins—the enzymes at the heart of the proteolytic γ-secretase complex that unleashes Aβ peptides—are essential to prevent age-related cognitive deficits and neurodegeneration...
The inside of a cell is a very busy place...
Just grind some dehydrated blueberries into your people-chow and counteract the effects of aging and Alzheimer's disease on memory. That's one hypothesis we can take away from a recent study by Jim Joseph and colleagues...
Studying the interaction of genes and environment just got even more complicated...
Three groups presented results of their ongoing effort to incorporate scientific advances of the past quarter-century into a revision of the current diagnostic AD criteria...
If you want to make sure to remember something, sleep on it. Sleep research confirms this adage, and indeed, its chemical underpinnings may have surprising implications for Alzheimer’s disease treatment...
Clearly, the best way to avoid Alzheimer disease is not to grow old. But why?...
In American football, using your head may mean different things to different players...
Toxic marine algae can cause oceanic dead zones, suffocation in fish, insanity in marine mammals—and perhaps, neurodegenerative disease...
It is not just material goods that are best when they come in small packages, but amyloid-β (Aβ) as well...
Consider a study in last week’s online PNAS a reminder that one lab’s trash could be another’s treasure...
Two pernicious disorders of late life, Alzheimer disease and diabetes, may be tied together...
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