Ataxia Proteins Tied Together in Disease-related Interactome
Cerebellar ataxias form a large group of movement and balance disorders that result from degeneration of Purkinje cells...
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CSF Biomarkers—Maybe You Can See the Forest for the Trees
The prospects of using cerebrospinal fluid biomarkers to diagnose Alzheimer disease may have just gotten a bit brighter...
Of Cabbages and Rings—AD and the Vasculature
Two recent reports add to the growing evidence that trouble in the circulatory system can lead to...
DNA Deletions Sap Mitochondria in Parkinson Neurons
Mutations in mitochondrial DNA (mtDNA) accumulate in aging and Alzheimer disease, but their impact on cell physiology...
MARK Homologue Sparks Tau Terror in Fruit Fly
PAR-1, a homologue of microtubule-affinity regulating kinase (MARK), kicks off the phosphorylation events that culminate in cell death in a fly model of tauopathy, according to...
SfN: R-Flurbiprofen Phase 2 Trial Results
When it comes to human tests of prospective Alzheimer disease treatments, researchers have learned to be humble...
Merck Withdraws Vioxx®
Pharmaceutical giant Merck announced today that it was withdrawing rofecoxib, a pain and antiinflammatory drug, from worldwide markets...
Safety Concerns Halt ADAPT Trial
With safety concerns about celecoxib and now naproxen, the Alzheimer's Disease Antiinflammatory Prevention Trial has ground to a halt...
Amyloid Ligand Looks Suited for Future Diagnostic Test
Brian Bacskai and colleagues from Massachusetts General Hospital, Charlestown, and Bill Klunk and colleagues at the University of Pittsburgh, Pennsylvania, show that they can image the uptake, labeling of amyloid plaques, and subsequent release of the thioflavin derivative Pittsburgh compound B (PIB)...
New Marker for AD on the Horizon?
The chemokine receptor CCR1 might be an early and specific marker of Alzheimer's disease, researchers suggest in the November issue of Annals of Neurology, now available online...
AGEing Neurons Waste Away in Fly Model of Neurodegeneration
A genetic screen for mutations causing age-related neurodegeneration in fruit flies has uncovered a...
Salzburg Overview: 8th International Conference Draws Record Number
The International Conference AD/PD has been growing steadily; this year...
Glia—Absolving Neurons of Motor Neuron Disease
In courtroom dramas, the savvy attorney always manages an acquittal for the innocent defendant. Research dramas can be similar...
Charting Genetic Diversity—First Haplotype Map Appears
An international crew of investigators called the International HapMap Consortium published their first draft of the human haplotype chart...
HAI Chicago: PIB in Healthy People
Many studies using Pittsburgh Compound-B (PIB) have found a fair percentage of normal elderly walking around with heads full of amyloid...
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