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In the upcoming print issue of the Journal of Medicinal Chemistry, Italian researchers led by Allesandro Dalpiaz are reporting initial success in using Vitamin C to ferry drugs through the blood-brain barrier...
In last Friday's Nature, Lawrence Goldstein of the University of California, San Diego, further advanced his claim that the amyloid-β precursor protein (AβPP) mediates fast, anterograde axonal transport by binding to the motor protein kinesin-1...
In this week’s Neuron, researchers report that polyglutamine-expanded huntingtin (Htt)—the direct cause of Huntington's disease—exacerbates inositol triphosphate-mediated calcium signaling...
The triplet repeat disease X-linked spinal and bulbar muscular atrophy (SBMA) is caused by a polyglutamine expansion in the androgen receptor (AR) gene. Just how this expansion causes degeneration of lower motor neurons...
Ever since encephalitis halted development of Elan’s active vaccine for Alzheimer disease...
Organism-level experimental data now lend some support to the epidemiologic evidence that the fatty acids in fish oil can protect against Alzheimer disease...
Oxygen is a double-edge sword for cells: It is necessary for life, but at the same time it is the source of damaging free radicals that attack DNA, proteins and cell membranes...
After their production in endosomes, intraneuronal membrane-bound amyloid-β (Aβ) accumulates in multivesicular bodies (MVBs), but...
Raging autoimmune T cells were fingered as the culprits in the toxicity of the failed first-generation Alzheimer disease (AD) vaccine. Even so...
Mutations in Pink1, a gene coding for a mitochondrial protein kinase, has just been fingered as a genetic cause for parkinsonism. In today’s Sciencexpress, researchers report that Pink1 and PARK6, a long-sought-after genetic locus that is linked with early-onset Parkinson’s disease, are...
In last October’s Neuron, researchers revealed that the gene LRRK2, encoding a protein kinase dubbed “dardarin,” is one and the same with...
This month’s Archives of Neurology provides a gold mine of studies on the neuropathological correlates of...
Alzheimer disease rages in the brain long before plaques form, and even before...
Scientists have been racing to develop simple, non-invasive, and accurate tools for the early diagnosis of Alzheimer's disease (AD). Recently, brain imaging has received a boost by the findings of Silverman et al...
More women than men have Alzheimer's disease (AD), suggesting that loss of estrogen may increase the risk for AD in postmenopausal women. Recent studies to demonstrate that estrogen protects Alzheimer's patients have had mixed results...
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