A Better Tau Trap? Viral Somatic Transfer of Mutant Tau in Rats
Localized gene transfer has produced the first rat model of neurofibrillary tangles, announce the authors of a report in the January 2004 American Journal of Pathology...
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Erene Mina Reports on Presenilin’s Loops through the Membrane
While it is generally accepted that PS1 has eight transmembrane domains (8-TM), a paper in this week’s early online PNAS resurrects the hypothesis that PS1 assumes a 7-TM topology, and suggests it may have a role...
Exchange of Letters Asks if Silver Lining in Vaccine Trial Was Real
One bit of reassuring evidence tempered the dismay over the encephalitis cases that ended dosing in the phase 2 trial of an Aβ vaccine: At least the vaccine removed the plaques. Not so fast...
ATM Links DNA Damage to Neuronal Cell Cycle Activation and Apoptosis
In today’s Neuron, researchers report that ATM, or ataxia-telangiectasia mutated protein, mediates cell cycle activation and subsequent death of neurons in response to DNA damage...
DJ Chaperones α-Synuclein—Offers Cell Model of Parkinson Disease
New evidence suggests that DJ-1, which is mutated in some cases of early-onset Parkinson disease, acts as a chaperone that prevents aggregation of...
Poles Apart—The Tau Kinase GSK3β Separates Axons and Dendrites
Light and gravity ensure that tree trunks grow straight up while their roots burrow deep underground. What about neurons?...
A New BACE for Immunotherapy
Immunotherapy, through either passive or active immunization, remains a viable and aggressively pursued strategy for...
Stem Cells: New Ways to Make Them Branch Out
The allure of stem cells lies in their potential to treat a plethora of human degenerative diseases. However...
Mouse of a Different Color: Presenilin Mutations Affect Melanin
As the roster of substrates for the γ-secretase protease continues to swell, the presenilin (PS) proteins seem to be...
Mutant Tau Sharpens Wits of Young Mice
Recent work with mouse models of Alzheimer disease has driven home the idea that...
MCI—Hippocampal IDE, Parahippocampal White Matter in Decline
In the earliest stages of Alzheimer disease, Aβ is on the rise, especially in...
Endocannabinoids: Wet Blanket on Hippocampus Excitement
In Alzheimer disease and other neurodegenerative disorders, chronic activation of glutamatergic neurons may fuel excitotoxicity and neuronal death...
Enhancing Aβ Fibrillization Boosts Mouse Memory
While amyloid-β (Aβ) seems to have the majority vote for the protein culprit in Alzheimer disease (AD),...
Anesthesia and Cognitive Decline: No Link in Longitudinal Study
The most recent study on the long-term cognitive effects of anesthesia and surgery suggests that elderly people going under the knife have little reason to worry...
Inside Out—Plaques May Have Intracellular Origin
Researchers have, by and large, assumed that Aβ starts aggregating outside the cell...
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