Omega-3 Fatty Acid Target Identified in Neurite Extension
Everyone knows that omega-3 polyunsaturated fatty acids (PUFAs) are good for you (eat your fish!), but no one really knows why...
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The AICD Test? Transgenic Mice Show Neurodegeneration
The carving up of the APP by the successive action of β- and γ-secretases liberates Aβ, but also yields a small intracellular fragment, AICD...
New Players on the Parkinson's Field
Two research groups at Columbia University's Taub Institute have discovered new molecular partners for parkin and α-synuclein—proteins that, when mutated, cause early-onset familial forms of Parkinson's disease...
Aβ's Shadowy Sibling—What Becomes of the Intracellular Domain?
In the January 31 online PNAS, Meir Scheinfeld, Shuji Matsuda, and Luciano D'Adamio of the Albert Einstein College of Medicine in Bronx, New York, show how the carboxyl terminus of AβPP could play a significant role in gene transcription...
Philadelphia: European Trial of Alzhemed Ends, Marketing Morphs to Supplement
Neurochem announced last week that it would halt development of tramiprosate (Alzhemed)...
Scouting AD’s “Little League” Genes: Can Systems Biology Help?
Like baseball coaches selecting top prospects for their team, geneticists studying Alzheimer disease face a formidable challenge...
FRETting Pays off—NSAIDs Target Presenilins, Reduce Aβ42
Some NSAIDs have been shown to shift Aβ production to the shorter Aβ1-38. Now, results suggest that they do this by eliciting a conformational change in presenilin...
Excess Glutamate, Low Oxygen: Can Common Enzyme Mask Effects?
In the brain, too little oxygen or too much of the neurotransmitter glutamate are both bad news...
Visualizing Success with MRI of Amyloid Plaques in Live Mice
Researchers from the RIKEN Brain Science Institute in Saitoma, Japan are reporting a new MRI-based method for identifying amyloid deposits...
Bexarotene Revisited: Improves Mouse Memory But No Effect on Plaques
Researchers reported in 2012 that the cancer drug bexarotene swiftly cleared amyloid-β and restored memory in transgenic mouse models of Alzheimer's disease...
BACE Goes Rafting after APP
A new study adds support to the theory that a critical first step in the production of the Aβ peptide by the BACE enzyme occurs primarily in specialized, cholesterol-rich areas of the plasma membrane called "lipid rafts"...
Amyloid Hypothesis—Closing the Spigot Helps, Temporarily
According to the overflowing bathtub analogy, either a blocked drain (not enough clearance), an oversized faucet (too much production), or a combination, contributes to...
Is Motor Neuron Axonopathy behind Movement Problems in Alzheimer Disease?
Although motor deficits such as a characteristically abnormal gait have been documented in Alzheimer disease (AD),...
Support for the Brain—Import Stem Cells, or Pamper Your Own
It is a lot to ask of transplanted neuronal stem cells to...
γ-Secretase Drives Spine Formation Via Novel Substrate
The γ-secretase has come a long way since its original discovery as the protease responsible for the production of amyloid-β peptides during sequential cleavage of the amyloid precursor protein...
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