Insight Into Neuronal Asymmetry
Neurons are highly polarized cells, with certain proteins within them clearly restricted to specific regions of the plasma membrane. Yet they lack any obvious barriers to free protein diffusion...
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LTP Deficits Seen in Hsiao Mice
Several years ago, Karen Hsiao and colleagues at the University of Minnesota reported that mice containing an FAD mutant form of the human amyloid precursor protein (APP) are impaired in their ability to learn...
ApoE4 Affects Recovery from Head Injury
The E4 gene variant of apolipoprotein E (ApoE) confers an increased risk of developing AD, but the mechanisms by which it does so are not understood. ApoE plays a role...
Keith A. Crutcher Interviews Rachael Neve
Keith A. Crutcher Interviews Rachael Neve
Brian J. Cummings Interviews Paul Coleman
Brian J. Cummings Interviews Paul Coleman
Aileen Anderson Interviews Dennis Selkoe
Aileen Anderson Interviews Dennis Selkoe
Brian J. Cummings Interviews Hungtington Potter
Brian J. Cummings Interviews Hungtington Potter
Keith A. Crutcher Interviews John Trojanowski
Keith A. Crutcher Interviews John Trojanowski
American Society for Cell Biology: 38th Annual Meeting
American Society for Cell Biology 38th Annual Meeting: Tau Protein in Neurodegenerative Diseases American Society for Cell Biology 38th Annual Meeting: More About Tau American Society for Cell Biology 38th Annual Meeting: Novel Protein Binds to APP and Mi
American Society for Cell Biology 38th Annual Meeting: More About Tau
Maas et al. (Abstract 2285) studied how phosphorylation of two different regions in tau proteins affects binding of tau protein to the plasma-membrane (PM). The two major phosphorylation sites studied...
American Society for Cell Biology 38th Annual Meeting, San Francisco, 12-16 December, 1998
A special interest subgroup meeting on 'Tau protein in Neurodegenerative Diseases' was organized by Gloria Lee, University of Iowa. This was a timely and stimulating meeting...
American Society for Cell Biology 38th Annual Meeting: Tau Protein in Neurodegenerative Diseases
A special interest subgroup meeting on "Tau protein in Neurodegenerative Diseases" was organized by Gloria Lee, University of Iowa. This was a timely and stimulating meeting that was energized in large part by the recent discovery...
American Society for Cell Biology 38th Annual Meeting: Novel Protein Binds to APP and Microtubules
Zheng et al. (Abstract 516) described the characterization of PAT1, a novel protein that binds to an 11-residue segment of the amyloid precursor protein (APP) in yeast 2-hybrid assays...
American Society for Cell Biology 38th Ann Mtg: Chaperone Clings to Aβ
Holtzman et al. (Abstract 612) reported that 95% of immunoreactive β-amyloid in human cerebral spinal fluid is bound to the ER chaperone Erp57...
American Society for Cell Biology 38th Annual Meeting: A Lethal Double Knockout
Harada et al. (Abstract 902) have now disrupted the MAP2 gene in mouse. Like tau and MAP1B knockout mice, MAP-2 knockout mice are fertile and have apparently normal brain cytoarchitecture...
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