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Some of the attention focused on amyloid-β may have to be diverted to yet another peptide product of amyloid precursor protein (APP). Daniel Lu, Edward Koo and colleagues report in the April issue of Nature Medicine that...
Inhibiting cell death proteases, or caspases, can prolong the life of mice with the fatal motor neuron disease amyotrophic lateral sclerosis (ALS), Robert Friedlander...
Chris Weihl Interviews Marsel Mesulam
Researchers from the Medical University of Lubeck in Germany say that they have failed to replicate the tantalizing evidence from a study published two years ago that found <em>Chlamydia</em> in almost all the Alzheimer's brains examined...
Conventional wisdom has it that each member of the large G protein-coupled receptor (GPCR) family pairs up exclusively with another of its own kind. But a new study in tomorrow's Science reports that two different GPCRs...
A central controversy in the Alzheimer's field has been the issue of whether amyloid plaques, comprising primarily Aβ peptide, correlate with the severity of dementia. Inconsistent findings on this point have fueled arguments...
Mel Feany and Welcome Bender of Harvard Medical School have succeeded in creating a transgenic <em>Drosophila melanogaster</em> model of Parkinson's, and surprisingly, have demonstrated that the flies feature...
Kazemi-Esfarjani and Benzer of California Institute of Technology report in today's Science the discovery of two genes that protect against eye degeneration resulting from aggregation of polyglutamines in <em>Drosophila</em>...
Insulin-degrading enzyme (IDE) plays a role in breaking down Aβ outside of neurons, report Dennis Selkoe, Konstantinos Vekrellis, and their colleagues at Harvard in the March 1 issue of the Journal of Neuroscience...
For more than a decade, a case has been building for the involvement of inflammatory processes in the pathogenesis of Alzheimer's disease. Now researchers say they have found definitive evidence...
A team led by Thomas Meade at the California Institute of Technology has developed an MRI contrast agent that is activated only in the presence of a target gene, according to a report in the March issue of Nature Biotechnology...
Circumstantial evidence has accumulated over the last decade that there are pluripotent stem cells in the hippocampus of humans and other animals. Much hope has been attached to these heretofore elusive cells because...
The Ts65Dn mouse developed at the Jackson Laboratory in Bar Harbor, Maine, has the signature skull and facial deformities of Down's syndrome, strengthening its case as a model for the human syndrome...
Previous studies have shown that women who take estrogen reduce their risk of developing Alzheimer’s disease. But can estrogen also benefit women who already have been diagnosed with the disease?...
Memory deficits due to NMDA receptor loss in the hippocampus can be overcome by enriched environments, according to a report from Joe Tsien and his Princeton colleagues in the March issue of Nature Neuroscience...
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