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It's a poorly kept secret that Aβ peptides are highly inconsistent in their neurotoxic properties. One batch of synthetic peptide will kill neurons handily, while another will be benign...
One of the earliest clues that apoE may contribute to AD pathology was the immunohistochemical demonstration by Namba and colleagues that ApoE was present in both plaques and tangles...
The award for most aesthetically pleasing presentation almost certainly could go to Dr. Paul Thompson, who reviewed recent advances being made by a UCLA team in developing AD-specific brain atlases for assessing alterations in the brain over time...
At least I hope they will come. Brian Cummings presented an overview of a web-based database for Alzheimer’s cases (known as the Neuropathological Examination Research Database or NERD) that could serve as a model for other AD centers...
A number of lines of evidence implicate oxidative damage caused by free radicals—particularly reactive oxygen species—as having some role, perhaps even a major or causative one, in the etiology of neurodegenerative diseases...
Douglas Kerr and colleagues at Johns Hopkins (Abstract 209.13) reported success in using neural stem cells to restore function in an animal model of spinal motor atrophy (SMA). In SMA, the ventral horn motor neurons...
Parkinson's disease is one of the most common neurodegenerative diseases, affecting about one percent of all people over the age of 65. It is characterized by rigidity, bradykinesia and tremors, which are caused by the progressive degeneration of dopamine-containing neurons...
A central problem in Alzheimer's disease is to understand how Aβ affects the brain's biology, and how it contributes to neurodegeneration. A diverse array of mechanisms have been proposed...
It is not only the abnormal product of amyloid precursor protein—the amyloid-β peptide—that interests researchers of Alzheimer's disease. There is also a line of inquiry that hopes to find clues to the disease in the normal function of amyloid precursor protein...
William Harvey Research Conference: The Role of COX-2 Inhibitors in Inflammatory and Other Diseases William Harvey Research Conference
A new study published today in Science finds that GDNF genes delivered by a lentiviral vector reversed functional deficits and prevented neurodegeneration in a primate model...
The 15 invited conference speakers reported their most current findings on cyxlooxygenase (COX-1 and COX-2) inhibitor research including the latest technical developments concerning the relevance of COX-2...
Gene Therapy Rescues Neurons in Parkinson's Model American Neurological Association: 2000 Annual Meeting
Neural stem cells have been heralded as a potential therapy to rebuild injured and diseased brain tissue, but to achieve that vision, researchers must decipher the molecular signals that direct the cells to migrate through the brain...
A two-gene therapy strategy prevents the death of dopamine neurons and preserves their function, according to a study by Jorg Schulz and colleagues at the University of Tubingen in Germany...
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