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Mild cognitive impairment (MCI) has been defined as a clinical entity whose characteristics were reviewed by Ron Petersen. Persons with MCI have memory impairment beyond what would be expected for age, yet they are not demented...
There were a number of oral and poster presentations at the World Alzheimer Congress 2000 relating to BACE biology...
The scientific highlight of the Prof. Henry Wisniewski memorial symposium (12 July) was an informative lecture about familial British dementia (FBD)...
Almost 12% (152) of the 1307 abstracts presented at the 7th International Conference on Alzheimer’s Disease and related disorders made reference to presenilin (PS)...
One of the great unsolved mysteries of Alzheimer's disease is the link between the disease's two major lesions: β amyloid plaques and tau tangles...
Several late-breaking, dramatic results were presented at this final symposium of the World Alzheimer Congress 2000...
Michael Hutton and colleagues from Mayo Laboratory, Jacksonville, revealed that double transgenics expressing the Swedish APP mutation and P301L tau also had NFTs and neuropathology...
Although there are many reports of neurotoxic effects of amyloid when applied to neurons in culture, the evidence for toxicity in vivo has been...
The centrality of the amyloid hypothesis for AD pathology is evident at the World Alzheimer Congress 2000, not only by the sheer number of papers and posters devoted to it, but also by...
The potential contribution of ApoE to AD pathology was cast in a novel light in data presented as a poster today by Huang et al. They were studying the fate of ApoE when expressed by transient transfection in Neuro-2a cells...
It has been a century since Alzheimer and Bielchowsky reported senile plaques (SP) in AD brain, but it was only relatively recently appreciated that SPs are embraced by reactive astrocytes and microglia...
Do individual neurons gradually waste away in inherited neurodegenerative diseases, or are they functioning more or less normally until one catastrophic event does them in? A study published in tomorrow's Nature suggests...
One of the first symposia of the conference was dedicated to an overview of the current and future treatments for AD. Six presenters gave their perspectives on many treatment issues...
Amyloid plaques are still the main attraction, and tangles have certainly not left the stage, but there is still a lot of interest at this meeting (off-Broadway, so to speak) in other potential players in AD pathology...
The editors of the Journal of Alzheimer Disease announced today that Suzanne de la Monte was the recipient of its Alzheimer Medal for best article published in the past year...
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