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Three independent studies published in the 22 December issue of Science reported that chromosome 10 probably harbors one or more genes that confer an increased susceptibility to late-onset Alzheimer's disease...
Symposium: Gene Expression Profiling of Alzheimer's Disease American College of Neuropsychopharmacology 2000 Annual Meeting
At the Annual Meeting of the American College of Neuropsychopharmacology, San Juan, Puerto Rico, the speakers discussed the sequence of changes in gene expression in the brain that may take place during the transition from normal...
The drug selegiline, thought to be neuroprotective, has been used to treat Parkinson's disease for the past 25 years, but a report a few years ago suggested that the drug could accelerate death in patients taking it...
In today's issue of Science, researchers at the Whitehead Institute and Corning Inc. describe a new microarray technique that can decipher the function of master switches in a cell by identifying the set of genes they control across the entire genome...
A study presented earlier this week at the 2000 International Chemical Congress of Pacific Basin Societies in Honolulu found that by manipulating the structure of amyloid-β, it was possible to reduce the peptide's ability...
Society for Neuroscience Annual Meeting: Stem Cells Drawn to Aβ Society for Neuroscience Annual Meeting: Stem Cells Promising for Motor Neuron Disorders Society for Neuroscience Annual Meeting: Does ApoE Contribute to Tangle Formation? Society for Neurosc
The 40th ASCB meeting began its grand kick-off on Saturday December 9 with an opening symposium by four Nobel Laureates, J. Michael Bishop, Joseph Goldstein, Michael Brown, and Harold Varmus. Bishop summarized his discovery of proto-oncogenes...
A trio of articles will appear in tomorrow's issue of Nature, reporting that Aβ peptide immunization reduces a memory deficit in transgenic mouse models of AD...
The molecular and genetic mechanisms involved in the initiation and progression of Alzheimer’s disease (AD) are poorly understood. One emerging player in the proinflammatory cycle operating in AD brain...
Widespread reports of changes in RNA message abundance and specific RNA message levels in senescent cultured primary neural cells, in normal aging human brain and especially in Alzheimer’s disease-afflicted neocortex and hippocampus suggest...
Bertram et al. (301.7), evaluated Alzheimer’s disease (AD) candidate genes and AD chromosomal regions of interest (`30 cM) from the whole genome scans available...
The presenilin-1 and -2 (PS1, PS2) genes encode integral transmembrane proteins putatively involved in cell-cell recognition, cell-fate determination, intercellular signaling and Aβ peptide formation...
Presenilin-1 and -2 (PS1, PS2) gene mutations appear to cause the majority of cases of early-onset familial Alzheimer’s disease (EO-FAD). In this presentation Potter et al. (492.2) presented data...
Presenilin-1 and -2 (PS1 and PS2) are members of a (growing) family of genes which encode polytopic integral transmembrane proteins homologous to the Notch cell surface receptors of <em>Drosophila</em>...
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