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Researchers from France reported success in synthesizing novel compounds that specifically target γ-secretase cleavage of amyloid-β (Aβ) peptide, without affecting the enzyme's cleavage of other substrates...
Immune Network Ltd. reported last week that the company's Canadian Phase I clinical study has been halted due to an unexplained...
Stem cells from mouse bone marrow can help repair muscle killed in heart attacks, Piero Anversa and his team at New York Medical College, New York, and colleagues, show in [the 5 April issue of] Nature...
A team at Dartmouth College, New Hampshire, has developed a brain-image repository that will make it possible for scientists to freely share fMRI data with colleagues worldwide...
Chris Weihl Interviews Sam Gandy
The abnormal form of the protein huntingtin may exert its toxic effects on neurons in Huntington's disease by interfering with a protein essential for gene transcription, according to a study published in this week's issue of Science...
It is now generally accepted that new neurons are generated in the adult mammalian brain, but until now it has been unclear whether or not these neurons are essential for memory formation...
A British and German team has made the surprising discovery that the cell's mitochondria can export peptides into their surrounding environments. Much is known about how mitochondria import proteins, but the role of this unexpected export mechanism...
Understanding the mechanisms regulating brain wiring has until now relied on biochemical purification approaches in vertebrates and genetic approaches in invertebrates to identify molecular clues. This week...
This week Peter Chien and Jonathan Weissman of the University of California, San Francisco, explain how they used two species of yeast (and an artificial yeast prion protein to investigate how prions jump the species barrier...
Aggregated proteins, or amyloids, are seen in a wide variety of neurodegenerative diseases, including Alzheimer's and Creutzfeldt-Jakob (CJD) disease. Such aggregates are generally considered to be aberrant formations...
On February 28, 2001, the U.S. Food and Drug Administration (FDA) approved Reminyl® (galantamine hydrobromide) for the treatment of mild to moderate Alzheimer's disease...
The most promising target for an Alzheimer's therapy in the short term may be the enzyme β-secretase, suggest two papers in the March issue of Nature Neuroscience. Two separate groups have found that mice lacking the BACE1...
Deleting a critical gene for iron metabolism leads to selective neurodegeneration, according to a study in this month's Nature Genetics. When researchers ablated the gene for iron regulatory protein 2 (IRP2), they produced...
The Memory Evaluation and Treatment Service at Burke Medical Research Institute has started a therapeutic trial of a nutritional supplement...
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