Antibody Clears Prion Infection
While therapeutic Aβ antibodies are wending their way through clinical trials, researchers studying other offending brain proteins have been racing to work out similar strategies...
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Neurofilaments May Be Essential to Some Tauopathies
It appears that some tauopathies require the presence of neurofilaments for neurodegeneration to occur. In the 15 August Journal of Neuroscience, Virginia Lee, Takeshi Ishihara, and colleagues at the University of Pennsylvania describe...
Putting Parkinson's Placebo Effect on a Chemical Footing
A study published in May in the New England Journal of Medicine questioned long-held views on the placebo effect, sparking intense debate...
Erythropoietin a Neuroprotectant?
Pretreatment with the hormone erythropoietin (EPO) can protect neurons in models of neurodegenerative and stroke-related cell death, according to a paper in today's Nature...
Enabling Technologies 2001 Workshop Summary
In August 2001, a diverse group of academic and industry investigators from within and outside of Alzheimer's disease research participated in this workshop in Bar Harbor, Maine.
Summary of Scientific Discussions: Bar Harbor
Robert Balaban opened the discussion by observing that heart disease and AD research share certain characteristics, including a weak familial linkage, poor penetrance of some of the known risk factors, and a poor understanding of the interplay between environmental and behavioral factors with gene-gene interactions.
Summary of Technology Discussions: Bar Harbor
Tim Clark began by laying out recommendations about the information infrastructure required if many groups want to be able to do collective experimentation, to share data, and to exploit automated pattern recognition in that shared data.
Enabling Technologies for Alzheimer Disease Research: 2001 Bar Harbor Workshop
Enabling Technologies 2001 Workshop Summary Summary of Scientific Discussions: Bar Harbor Summary of Technology Discussions: Bar Harbor Enabling Technologies for Alzheimer Disease Research: 2001 Bar Harbor Workshop
Challenging Views of Alzheimer's Disease
Challenging Views of Alzheimer's Disease: Meeting Notes Challenging Views of Alzheimer's Disease
Challenging Views of Alzheimer's Disease: Meeting Notes
This meeting was born of a disenchantment with the regular conference format that usually consists of numerous data-oriented talks with limited or no opportunity for critical discussion...
Making the Search for Snips More Parallel
In the search for those mostly still-elusive SNPs that are widely thought to predispose to complex, multigenic diseases such as schizophrenia and heart disease, one technical hurdle that slows down the search is the sheer amount of sequencing required...
Study Suggests Neural Stem Cells Generate Brain Containing Multiple Reservoirs for Repair
As the political debate about stem cell research heats up once again, scientists continue to wrestle with the most fundamental questions about these cells: Where do they come from? Are the stem cells...
Evidence on Iron Accumulates
It has been clear for a number of years that iron accumulates in areas such as the hippocampus in Alzheimer's disease and the substantia nigra in Parkinson's disease. Just what this means is...
European Alzheimer's Disease Consortium Launched
Thirty European Alzheimer's Disease Centers of Excellence and one nongovernmental organization, Alzheimer Europe, have established a network to carry out multicentre interventional trials under the auspices of the European Commission...
Long-elusive Function for APP Cleavage Product Comes into View: It's Gene Transcription
It has become part of the standard lore on Alzheimer's that a series of enzymes—dubbed α-, β-, and γ-secretase—successively chops away at the APP cell-surface protein...
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