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Astrocytes are the stem cells that generate new neurons in the mammalian hippocampus, according to a report in the September 15 Journal of Neuroscience. This result appears to match results from the subventricular zone...
One of the most pressing needs in Alzheimer's research today is the ability to identify, among normal elderly people, those who will likely go on to develop AD. A paper published today...
The dominant theory of Alzheimer's disease is that insoluble aggregates of amyloid-β (Aβ) are the neurotoxic entity that causes neuronal dysfunction and cell death...
Two apparently contradictory reports in the August 11 Lancet have injected new fuel into the debate about the role of inflammation in Alzheimer's disease...
Two papers in tomorrow's Science provide ong-awaited evidence for the notion that the two pathological hallmarks of Alzheimer's disease are interconnected. Using different approaches...
Thomas Wisniewski, Einar Sigurdsson, and colleagues at New York University report that they have prevented amyloid-β deposition by immunizing a mouse model of Alzheimer's disease with a nontoxic Aβ homologue...
In the August 16 Nature, scientists in the laboratory of Perry Bartlett, at the Walter and Eliza Hall Institute of Medical Research, Victoria, Australia, report the successful isolation of multipotent stem cells from adult mice...
Spinal muscular atrophy with respiratory distress type 1 (SMARD1), a life-threatening disease that strikes infants as young as four weeks, is due to loss of neurons in the anterior horn of the spinal cord...
While therapeutic Aβ antibodies are wending their way through clinical trials, researchers studying other offending brain proteins have been racing to work out similar strategies...
It appears that some tauopathies require the presence of neurofilaments for neurodegeneration to occur. In the 15 August Journal of Neuroscience, Virginia Lee, Takeshi Ishihara, and colleagues at the University of Pennsylvania describe...
A study published in May in the New England Journal of Medicine questioned long-held views on the placebo effect, sparking intense debate...
Pretreatment with the hormone erythropoietin (EPO) can protect neurons in models of neurodegenerative and stroke-related cell death, according to a paper in today's Nature...
In August 2001, a diverse group of academic and industry investigators from within and outside of Alzheimer's disease research participated in this workshop in Bar Harbor, Maine.
Robert Balaban opened the discussion by observing that heart disease and AD research share certain characteristics, including a weak familial linkage, poor penetrance of some of the known risk factors, and a poor understanding of the interplay between environmental and behavioral factors with gene-gene interactions.
Tim Clark began by laying out recommendations about the information infrastructure required if many groups want to be able to do collective experimentation, to share data, and to exploit automated pattern recognition in that shared data.
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