Building Blocks for Neurodegenerative Disease Therapy
Two papers published this week offer data that might further the search for therapies in neurodegenerative disease, particularly in Parkinson's...
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Protein Chimera Found to Protect Axons from Degeneration
It has been known since Waller's description in 1850 that axons of damaged neurons degenerate on the distal side of the lesion. Wlds mice exhibit slow Wallerian degeneration, but while they are known to harbor an 85 kb tandem triplication...
Yet Another Molecular Partner for Presenilins Identified
Researchers from Bart de Strooper's lab at the Flanders Interuniversity Institute for Biotechnology, reported in the 20 November Neuron that telencephalin (TLN), a member of the intercellular adhesion molecule (ICAM) family, binds to presenilins 1 and 2...
Society for Neuroscience Annual Meeting 2001
Post-Conference News: Oligomers, Protofibrils, and Fibrils—They Are All Bad Post-Conference News: Fly-Fishing for γ-Secretase Function and Substrates Society for Neuroscience Annual Meeting 2001
Post-Conference News: Fly-Fishing for γ-Secretase Function and Substrates
A number of presentations at this year's Society for Neuroscience meeting provided new insight into the biology of presenilin. First, about its function. Deletion of the notch receptor in Drosophila produces a characteristic, hypomorphic phenotype...
Post-Conference News: Oligomers, Protofibrils, and Fibrils—They Are All Bad
Extensive data supporting a central role for Aβ in the genesis of Alzheimer's disease notwithstanding, the amyloid hypothesis has its weaknesses...
Is There a Genetic Basis for Idiopathic Parkinson's Disease?
The debate over the etiology of Parkinson's disease (PD) has been spurred by an article in the November 14 Journal of the American Medical Association, in which the authors contend that genetics, not just environmental factors...
Gene Chip Analysis in Single Neurons Suggests Expression of Synaptic Proteins
RNA profiling is increasingly being used in the study of Alzheimer's disease, but interpreting the pretty microarray patterns can be difficult. To name but one problem, individual neurons vary greatly in their degree of pathology...
Two New Developments in the Search for Alzheimer's Biomarkers
One of the most coveted achievements AD researchers are striving for these days is to develop a biomarker that could, simply and inexpensively, detect if a person has early Alzheimer's disease...
Finally Introducing: A Mouse with Wildtype Human Tau That Makes Tangles
For years, scientists have tried to create transgenic mice that form neurofibrillary tangles, one of the two pathological hallmarks of Alzheimer's disease. All attempts failed until last year...
The Gene Within a Gene: Could Tau "Junk DNA" Harbor Risk Factor for AD?
In a preliminary but tantalizing finding, Chris Conrad and coworkers reported today that they have found a novel, small gene in an intron of the tau gene, and that this new gene has a single-nucleotide polymorphism...
Long-Term Follow-up of Parkinson's Patients Who Received Embryonic Cell
A bold, but also much-criticized, experimental therapy for Parkinson's disease involves injecting dopaminergic, human embryonic neurons into a dopamine-depleted brain area of patients...
Cognitive Deficits in Parkinson's Disease Yield Clues about Basal Ganglia's Role in Learning
If you thought Parkinson's disease is simply a motor disorder, think again. In recent years, researchers have increasingly realized that the disease has a cognitive component as well...
More on BACE1, the New Darling of Alzheimer's Disease Drug Developers
The β-secretase enzyme BACE1 become an instant favorite among researchers interested in developing small-molecule drugs against Alzheimer's disease...
Fog Beginning to Clear on Aβ-Degrading Enzymes?
There are two principal ways by which the Aβ accumulation seen in the brains of people with AD can occur. One—overproduction by β- and γ-secretases...
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